Results 31 to 40 of about 2,619,685 (255)

Directed evolution reveals the mechanism of HitRS signaling transduction in Bacillus anthracis.

PLoS Pathogens, 2020
Two component systems (TCSs) are a primary mechanism of signal sensing and response in bacteria. Systematic characterization of an entire TCS could provide a mechanistic understanding of these important signal transduction systems.
Hualiang Pi, Michelle L Chu, Samuel J Ivan, Casey J Latario, Allen M Toth, Sophia M Carlin, Gideon H Hillebrand, Hannah K Lin, Jared D Reppart, Devin L Stauff, Eric P Skaar   +10 more
doaj   +1 more source

Prostaglandin E2 as transduction enhancer affects competitive engraftment of human hematopoietic stem and progenitor cells

Molecular Therapy: Methods & Clinical Development, 2023
Ex vivo gene therapy (GT) is a promising treatment for inherited genetic diseases. An ideal transduction protocol should determine high gene marking in long-term self-renewing hematopoietic stem cells (HSCs), preserving their repopulation potential ...
Valentina Poletti, Annita Montepeloso, Danilo Pellin, Alessandra Biffi   +3 more
doaj   +1 more source

Purinergic mechanosensory transduction and visceral pain [PDF]

, 2009
In this review, evidence is presented to support the hypothesis that mechanosensory transduction occurs in tubes and sacs and can initiate visceral pain.
Geoffrey Burnstock, Burnstock, G, Burnstock Geoffrey   +2 more
core   +1 more source

Depletion of essential mycobacterial gene glmM reduces pathogen survival and induces host-protective immune responses against tuberculosis

Communications Biology
The limitations of TB treatment are the long duration and immune-dampening effects of anti-tuberculosis therapy. The Cell wall plays a crucial role in survival and virulence; hence, enzymes involved in its biosynthesis are good therapeutic targets. Here,
Meetu Agarwal, Ashima Bhaskar, Biplab Singha, Suparba Mukhopadhyay, Isha Pahuja, Archna Singh, Shivam Chaturvedi, Nisheeth Agarwal, Ved Prakash Dwivedi, Vinay Kumar Nandicoori   +9 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

In vitro and in vivo validation of human and goat chondrocyte labeling by green fluorescent protein lentivirus transduction [PDF]

, 2010
We investigated whether human articular chondrocytes can be labeled efficiently and for long-term with a green fluorescent protein (GFP) lentivirus and whether the viral transduction would influence cell proliferation and tissue-forming capacity.
Candrian, Christian, Gianni-Barrera, Roberto, Juelke, Henriette, Martin, Ivan, Jaquiery, Claude, Acharya, Chitrangada, Barbero, Andrea, Miot, Sylvie, Pelttari, Karoliina, Mainil-Varlet, Pierre, Mainil-Varlet P, Acharya C, Barbero A, Pelttari K, Candrian C, Miot S, Martin I, Juelke H, Jaquiery C, Gianni-Barrera R   +19 more
core   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Advances in Targeting Signal Transduction Pathways [PDF]

, 2012
Over the past few years, significant advances have occurred in both our understanding of the complexity of signal transduction pathways as well as the isolation of specific inhibitors which target key components in those pathways.
Laidler, Piotr, Martelli, A. M., Milella, Michele, Davis, Nicole M., Mijatovic, Sanja, Cocco, Lucio, Fagone, Paolo, Libra, Massimo, Drobot, Lyudmyla, Steelman, Linda S., Nicoletti, Ferdinando, Baesecke, Joerg, Maksimovic-Ivanic, Danijela, Ligresti, Giovanni, Dulinska-Litewka, Joanna, Chiarini, Francesca, Abrams, Stephen L., Cervello, Melchiorre, Evangelisti, Camilla, Mazzarino, Maria C., Malaponte, Grazia, Demidenko, Zoya N., McCubrey, James. A., Montalto, Giuseppe, Franklin, Richard A., Donia, Marco, Sun, Lin, Talamini, Renato, Tafuri, Agostino, Umezawa, Kazuo, Chappell, William H., Candido, Saverio, Polesel, Jerry, D’Assoro, Antonio B.   +33 more
core   +6 more sources

Proteomic Profile Regulated by the Immunomodulatory Jusvinza Drug in Neutrophils Isolated from Rheumatoid Arthritis Patients

Biomedicines
Jusvinza is an immunomodulatory drug composed of an altered peptide ligand (APL) designed from a novel CD4+ T cell epitope of human heat shock protein 60 (HSP60), an autoantigen involved in the pathogenesis of rheumatoid arthritis (RA).
Mabel Hernández-Cedeño, Arielis Rodríguez-Ulloa, Yassel Ramos, Luis J. González, Anabel Serrano-Díaz, Katharina Zettl, Jacek R. Wiśniewski, Gillian Martinez-Donato, Gerardo Guillen-Nieto, Vladimir Besada, María del Carmen Domínguez-Horta   +10 more
doaj   +1 more source

A survey of genetic improvement search spaces [PDF]

, 2019
Genetic Improvement (GI) uses automated search to improve existing software. Most GI work has focused on empirical studies that successfully apply GI to improve software's running time, fix bugs, add new features, etc. There has been little research into
Alexander, B, Petke, Justyna, Alexander, Brad, Petke, J, White, DR, Wagner, M., Barr, ET, White, David R, Wagner, M, Barr, Earl T, Alexander, B., White, D.R., Petke, J., Barr, E.T., Brownlee, AEI, Brownlee, Alexander E I, Wagner, Markus, Brownlee, A.E.I.   +17 more
core   +1 more source