Results 51 to 60 of about 418,457 (205)

Depletion of essential mycobacterial gene glmM reduces pathogen survival and induces host-protective immune responses against tuberculosis

Communications Biology
The limitations of TB treatment are the long duration and immune-dampening effects of anti-tuberculosis therapy. The Cell wall plays a crucial role in survival and virulence; hence, enzymes involved in its biosynthesis are good therapeutic targets. Here,
Meetu Agarwal, Ashima Bhaskar, Biplab Singha, Suparba Mukhopadhyay, Isha Pahuja, Archna Singh, Shivam Chaturvedi, Nisheeth Agarwal, Ved Prakash Dwivedi, Vinay Kumar Nandicoori   +9 more
doaj   +1 more source

Prostaglandin E2 as transduction enhancer affects competitive engraftment of human hematopoietic stem and progenitor cells

Molecular Therapy: Methods & Clinical Development, 2023
Ex vivo gene therapy (GT) is a promising treatment for inherited genetic diseases. An ideal transduction protocol should determine high gene marking in long-term self-renewing hematopoietic stem cells (HSCs), preserving their repopulation potential ...
Valentina Poletti, Annita Montepeloso, Danilo Pellin, Alessandra Biffi   +3 more
doaj   +1 more source

Transduction of the genetic determinant for streptolysin S in group A streptococci [PDF]

Infection and Immunity, 1982
The genetic determinant for streptolysin S production (SLS+) was successfully transduced to two naturally occurring nonhemolytic strains of group A streptococci (Streptococcus pyogenes), an M-type 18 strain associated with an outbreak of rheumatic fever and an M-negative variant of a type 49 strain isolated from a skin lesion.
S A, Skjold, W R, Maxted, L W, Wannamaker   +2 more
openaire   +2 more sources

Tropism-modification strategies for targeted gene delivery using adenoviral vectors [PDF]

, 2010
Achieving high efficiency, targeted gene delivery with adenoviral vectors is a long-standing goal in the field of clinical gene therapy. To achieve this, platform vectors must combine efficient retargeting strategies with detargeting modifications to ...
Coughlan, L., Raul Alba, Coughlan, Lynda, Mcneish, I.A., Andrew H. Baker, Iain A. McNeish, Alba, R., Lynda Coughlan, Parker, Alan L., Nicklin, Stuart A., Bradshaw, Angela C., Bradshaw, A.C., Nicklin, S., Angela C. Bradshaw, Alan L. Parker, Stuart A. Nicklin, McNeish, Iain A., Baker, Andrew H., Parker, A.L., Alba, Raul, Baker, A.   +20 more
core   +1 more source

Proteomic Profile Regulated by the Immunomodulatory Jusvinza Drug in Neutrophils Isolated from Rheumatoid Arthritis Patients

Biomedicines
Jusvinza is an immunomodulatory drug composed of an altered peptide ligand (APL) designed from a novel CD4+ T cell epitope of human heat shock protein 60 (HSP60), an autoantigen involved in the pathogenesis of rheumatoid arthritis (RA).
Mabel Hernández-Cedeño, Arielis Rodríguez-Ulloa, Yassel Ramos, Luis J. González, Anabel Serrano-Díaz, Katharina Zettl, Jacek R. Wiśniewski, Gillian Martinez-Donato, Gerardo Guillen-Nieto, Vladimir Besada, María del Carmen Domínguez-Horta   +10 more
doaj   +1 more source

Developmental signal transduction pathways uncovered by genetic suppressors [PDF]

Proceedings of the National Academy of Sciences, 1996
We have found conditions for saturation mutagenesis by restriction enzyme mediated integration that result in plasmid tagging of disrupted genes. Using this method we selected for mutations in genes that act at checkpoints downstream of the intercellular signaling system that controls encapsulation in Dictyostelium ...
G, Shaulsky, R, Escalante, W F, Loomis
openaire   +2 more sources

APPENDIX. MODELING, SIMULATION AND APPLICATION OF BACTERIAL TRANSDUCTION IN GENETIC ALGORITHMS

, 2014
Supplementary material of the paper published in: International Journal "Information Technologies & Knowledge" Vol.7, Number 1, 2013: 11-22. At present, all methods in Evolutionary Computation are bioinspired by the fundamental principles of neo ...
J. Castellanos (607954), C. Perales-Gravan (607952), J. de Vicente Buendia (607953), Rafael Lahoz-Beltra (606073)   +3 more
core   +1 more source

Dynamic signal processing by ribozyme-mediated RNA circuits to control gene expression [PDF]

, 2014
Organisms have different circuitries that allow converting signal molecule levels to changes in gene expression. An important challenge in synthetic biology involves the de novo design of RNA modules enabling dynamic signal processing in live cells. This
Satya Prakash, Landrain, Thomas E., Landrain, T.E., Kirov, Boris, Majer, Eszter, Alfonso Jaramillo, Shensi Shen, José-Antonio Daròs, Shen, Shensi, Shensi Shen, Daros, Jose-Antonio, Guillermo Rodrigo, Thomas E. Landrain, Daròs Arnau, José Antonio, Rodrigo, Guillermo, Prakash, Satya, Boris Kirov, Thomas E. L, Rodrigo Tarrega, Guillermo, Jaramillo, Alfonso, Eszter Majer, Kiro, Boris   +21 more
core   +1 more source

IRAK4 Deficiency in a Patient with Recurrent Pneumococcal Infections: Case Report and Review of the Literature

Frontiers in Pediatrics, 2017
Primary immunodeficiencies are genetic defects of the innate or adaptive immune system, resulting in a propensity to infections. The innate immune system is the first line of defense against pathogens and is critical to recognize microbes and start the ...
Karina Gobin, Mary Hintermeyer, Bertrand Boisson, Bertrand Boisson, Bertrand Boisson, Maya Chrabieh, Maya Chrabieh, Pegah Ghandil, Pegah Ghandil, Pegah Ghandil, Pegah Ghandil, Anne Puel, Anne Puel, Capucine Picard, Capucine Picard, Capucine Picard, Capucine Picard, Jean-Laurent Casanova, Jean-Laurent Casanova, Jean-Laurent Casanova, Jean-Laurent Casanova, Jean-Laurent Casanova, Jean-Laurent Casanova, John Routes, James Verbsky   +24 more
doaj   +1 more source

Mechanisms of genetic transduction.

, 2019
Generalized (top), specialized (middle), and lateral transduction (bottom). The viral genome (in red) first undergoes theta replication, followed by rolling circle replication. In lateral transduction, theta replication occurs prior to prophage excision.
Yin Ning Chiang (1718815), John Chen (346835), José R. Penadés (7163618)   +2 more
core   +1 more source