Results 71 to 80 of about 418,457 (205)

Exploiting natural and induced genetic variation to study hematopoiesis [PDF]

, 2011
PUZZLING WITH DNA Blood cell formation can be studied by making use of natural genetic variation across mouse strains. There are, for example, two mouse strains that do not only differ in fur color, but also in average life span and more specifically in ...
Gerrits, Alice,, Gerrits, Alice
core  

Mobile genetic elements in Clostridium difficile and their role in genome function.

, 2015
Approximately 11% the Clostridium difficile genome is made up of mobile genetic elements which have a profound effect on the biology of the organism. This includes transfer of antibiotic resistance and other factors that allow the organism to survive ...
Roberts, AP, Roberts, Adam P., Mullany, P, Allan, E, Mullany, Peter, Allan, Elaine   +5 more
core   +1 more source

Magnetofection enhances lentiviral-mediated transduction of airway epithelial cells through extracellular and cellular barriers [PDF]

, 2016
Gene transfer to airway epithelial cells is hampered by extracellular (mainly mucus) and cellular (tight junctions) barriers. Magnetofection has been used to increase retention time of lentiviral vectors (LV) on the cellular surface.
CASTELLANI, STEFANO, CONESE, MASSIMO, Sante Di Gioia, Clara Orlando, Stefano Castellani, DI GIOIA, Sante, Orlando, C., Massimo Conese, Annalucia Carbone, Carbone, A.   +9 more
core   +1 more source

Phosphate sink containing two-component signaling systems as tunable threshold devices [PDF]

, 2014
Synthetic biology aims to design de novo biological systems and reengineer existing ones. These efforts have mostly focused on transcriptional circuits, with reengineering of signaling circuits hampered by limited understanding of their systems dynamics ...
Elisenda Feliu (481165), Soyer, Orkun S, Birgit E. Scharf (652091), Steven L Porter, Orkun S. Soyer (242985), Varun B. Kothamachu (481164), Munia Amin, Kothamachu, Varun B., Soyer, Orkun S., Birgit E Scharf, Elisenda Feliu, Scharf, Birgit E, Varun B Kothamachu, Munia Amin (386302), Amin, Munia, Kothamachu, Varun B, Steven L. Porter (243401), Porter, Steven L., Orkun S Soyer, Porter, Steven L, Feliu, Elisenda, Scharf, Birgit E.   +21 more
core   +1 more source

Synthetic mechanoreceptor engineering: From genetic encoding to DNA nanotechnology-based reprogramming

Mechanobiology in Medicine
Precise modulation of mechanoreceptor-mediated signal transduction is crucial for decoding cellular mechanotransduction mechanisms and programming cell fate.
Sihui Yang, Zhou Nie
doaj   +1 more source

Increased in vivo transduction of AAV-9 cargo in Alport podocytes [version 1; peer review: 1 approved, 2 approved with reservations, 1 not approved]

Wellcome Open Research
Background Alport syndrome is a rare genetic disorder characterized by progressive kidney disease, hearing loss, and eye abnormalities. It is caused by variants in the COL4A3, COL4A4 or COL4A5 genes, which disrupt the synthesis, secretion and assembly of
Emily Williams, Kevin A. Goncalves, Shota Kaseda, Antony Adamson, Maryline Fresquet, Andrew Steinsapir, David R. Sherwood, Rachel Lennon, Gema Bolas   +8 more
doaj   +1 more source

Serum-free Erythroid Differentiation for Efficient Genetic Modification and High-Level Adult Hemoglobin Production

Molecular Therapy: Methods & Clinical Development, 2018
In vitro erythroid differentiation from primary human cells is valuable to develop genetic strategies for hemoglobin disorders. However, current erythroid differentiation methods are encumbered by modest transduction rates and high baseline fetal ...
Naoya Uchida, Selami Demirci, Juan J. Haro-Mora, Atsushi Fujita, Lydia N. Raines, Matthew M. Hsieh, John F. Tisdale   +6 more
doaj   +1 more source

The Influence of Murine Genetic Background in Adeno-Associated Virus Transduction of the Mouse Brain

, 2019
Adeno-associated virus (AAV) vectors have become an important tool for delivering therapeutic genes for a wide range of neurological diseases. AAV serotypes possess differential cellular tropism in the central nervous system.
Li, C., Hall, N.E., Samulski, R.J., Earley, L.F., Riddick, N., Itano, M.S., He, T.   +6 more
core   +1 more source

Phosphodiesterase 4D acts downstream of Neuropilin to control Hedgehog signal transduction and the growth of medulloblastoma

eLife, 2015
Alterations in Hedgehog (Hh) signaling lead to birth defects and cancers including medulloblastoma, the most common pediatric brain tumor. Although inhibitors targeting the membrane protein Smoothened suppress Hh signaling, acquired drug resistance and ...
Xuecai Ge, Ljiljana Milenkovic, Kaye Suyama, Tom Hartl, Teresa Purzner, Amy Winans, Tobias Meyer, Matthew P Scott   +7 more
doaj   +1 more source

Functional Analysis of the ZAG2 Promoter from Maize in Transgenic Tobaccos

Journal of Integrative Agriculture, 2012
: The function of the 3 040 bp sequence at the upstream translation starting site (ATG) of the ZAG2 gene, isolated from the maize genome, was studied.
Min-hui LU, Guo-ying WANG, Zheng MENG, Jian-hua WANG   +3 more
doaj   +1 more source