Results 71 to 80 of about 2,619,685 (255)
eLife, 2015 Alterations in Hedgehog (Hh) signaling lead to birth defects and cancers including medulloblastoma, the most common pediatric brain tumor. Although inhibitors targeting the membrane protein Smoothened suppress Hh signaling, acquired drug resistance and ...
Xuecai Ge +7 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Functional Analysis of the ZAG2 Promoter from Maize in Transgenic Tobaccos
Journal of Integrative Agriculture, 2012 : The function of the 3 040 bp sequence at the upstream translation starting site (ATG) of the ZAG2 gene, isolated from the maize genome, was studied.
Min-hui LU +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Targeted Gene Delivery through the Respiratory System: Rationale for Intratracheal Gene Transfer
Journal of Cardiovascular Development and Disease, 2019 Advances in DNA- and RNA-based technologies have made gene therapy suitable for many lung diseases, especially those that are hereditary. The main objective of gene therapy is to deliver an adequate amount of gene construct to the intended target cell ...
Michael G. Katz +7 more
doaj +1 more source
Transformation and transduction in soil by clay-adsorbed genetic material
, 2000 Transformation and transduction in soil by clay-adsorbed genetic ...
Vettori C, Franchi M, Gallori E
core
Sensory Transduction and Subjective Experience: Expression of eight genes in three senses suggests a radical model of consciousness [PDF]
, 2007 Recent research into whole genome mapping of the mouse brain has made possible direct investigation of the brain expression of unusual genes. A search of the Allen Brain Atlas database has provided genetic and neuro-anatomical evidence for widespread ...
Chris C. King
core
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
, 2003 Signal Transduction is a well-illustrated, coherent look at cellular signaling processes. Beginning with the basics, it explains how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and then shows how these inputs
Tatham, Peter E. R.(Life scientist) +2 more
core
, 2020 Lentiviral vectors are widely used in genetic modification of human and animal cells (lentiviral transduction) to enhance their therapeutic potential by expression of recombinant protective and trophic factors.
Solovyeva V. +3 more
core