Results 31 to 40 of about 518 (105)
Current Issues in Molecular Biology, 2021 Background: Rolling-circle replication (RCR) is a novel technology that has not been applied to cell-free DNA (cfDNA) testing until recently. Given the cost and simplicity advantages of this technology compared to other platforms currently used in cfDNA ...
Uzay Gormus +11 more
doaj +1 more source
Patient Perception of Negative Noninvasive Prenatal Testing Results
American Journal of Perinatology Reports, 2016 Objective To determine patient perception of residual risk after receiving a negative non-invasive prenatal testing result. Introduction Recent technological advances have yielded a new method of prenatal screening, non-invasive prenatal ...
A. Theresa Wittman +5 more
doaj +1 more source
Prenatal diagnosis of a de novo trisomy 20p detected by noninvasive prenatal testing
Clinical Case Reports, 2021 Prenatal diagnosis of trisomy 20p seems to be difficult, considering the capacity of ultrasound to detect mild dysmorphic. NIPT has good performance in detecting fetal trisomy 20p combined with low coverage WGS and karyotype analysis.
Xu Yan, Haiying Peng, Changjun Zhang
doaj +1 more source
Taiwanese Journal of Obstetrics & Gynecology, 2018 Objective: Noninvasive prenatal testing (NIPT) is widely used as a powerful screening tool to detect common aneuploidies. However, its application for detection of rare chromosomal abnormalities remains inconclusive.
Chung-Yuan Lee +8 more
doaj +1 more source
A Review of Virtual Twins in Physiologically‐Based Pharmacokinetic Modeling and Simulation
Clinical Pharmacology &Therapeutics, EarlyView.The novel application of Virtual Twins (VT) in PBPK (VT‐PBPK) presents the opportunity to advance precision dosing and accelerate the shift from one‐size‐fits‐all to targeted, individualized treatments. This review aims to: (1) critically evaluate existing research on the use of VTs in PBPK, (2) develop a conceptual definition of VT‐PBPK, (3) describe ...
Emily Mannix +4 more
wiley +1 more source
Social and medical need for whole genome high resolution NIPT
Molecular Genetics & Genomic Medicine, 2020 Background Two technological innovations in the last decade significantly influenced the diagnostic yield of prenatal cytogenetic testing: genomic microarray allowing high resolution analysis and noninvasive prenatal testing (NIPT) focusing on aneuploidy.
Malgorzata I. Srebniak +12 more
doaj +1 more source
Noninvasive prenatal molecular karyotyping from maternal plasma. [PDF]
PLoS ONE, 2013 Fetal DNA is present in the plasma of pregnant women. Massively parallel sequencing of maternal plasma DNA has been used to detect fetal trisomies 21, 18, 13 and selected sex chromosomal aneuploidies noninvasively.
Stephanie C Y Yu +10 more
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Calculation of Fetal Fraction for Non-Invasive Prenatal Testing
BioTech, 2021 Estimating the fetal fraction of DNA in a pregnant mother’s blood is a risk-free, non-invasive way of predicting fetal aneuploidy. It is a rapidly developing field of study, offering researchers a plethora of different complementary methods. Such methods
Matthew Cserhati
doaj +1 more source
Epilepsia, EarlyView.Abstract Objective Circulating small noncoding RNAs represent potential biomarkers of temporal lobe epilepsy (TLE). Recently, two transfer RNA fragments (tRFs), 5′tRF Glu‐CTC and Gly‐GCC, were found to be elevated in plasma samples collected in advance of a seizure in TLE patients, suggesting they may serve as potential wet biomarkers of seizure risk ...
Marie Soukupova +15 more
wiley +1 more source
A case of Ewing's sarcoma identified via noninvasive prenatal testing
Clinical Case Reports, 2020 Although noninvasive prenatal testing is not intended to identify maternal genomic information, it can provide other information that may lead to the incidental discovery of coexisting conditions including maternal malignancy.
Keiko Miyagami +6 more
doaj +1 more source