Results 51 to 60 of about 39,692 (215)

Development of a nalmefene formulation suitable for a community‐use auto‐injector

British Journal of Clinical Pharmacology, EarlyView.
Aim Time to onset of reversal is critical when treating opioid‐induced respiratory depression and hypoxia. This study aimed to develop a formulation of the opioid antagonist nalmefene with an increased absorption rate and reduced time to onset of reversal following intramuscular administration. Methods Several absorption enhancers were screened in rats,
Alessandra Cipriano, Manjunath S. Shet, Hugh Huang, Ronnie Ortiz, Garth T. Whiteside, Glen Apseloff, Stephen C. Harris   +6 more
wiley   +1 more source

MT‐RNR1 genotype testing for preventing aminoglycoside‐mediated ototoxicity: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, EarlyView.
Aminoglycosides are broad‐spectrum antibiotics used in the management of severe infections. Aminoglycosides are associated with nephrotoxicity and ototoxicity. Although dosing strategies such as once‐daily administration and therapeutic drug monitoring have reduced the incidence of nephrotoxicity, ototoxicity remains unpredictable and may occur at ...
John H. McDermott, Sian Hilton, Cinzia Dello Russo, Nicola Booth, Simon Drysdale, Philip Howard, Stephen Hughes, Mallinath Chakraborty, Helen McDevitt, Charlotte Alston, Maya Desai, Mike Beadsworth, Adam Reynolds, Serim Min, Katherine Payne, Munir Pirmohamed, William G. Newman   +16 more
wiley   +1 more source

Noninvasive vs invasive respiratory support for patients with acute hypoxemic respiratory failure.

PLoS ONE
BackgroundNoninvasive respiratory support modalities are common alternatives to mechanical ventilation in acute hypoxemic respiratory failure. However, studies historically compare noninvasive respiratory support to conventional oxygen rather than ...
Jarrod M Mosier, Vignesh Subbian, Sarah Pungitore, Devashri Prabhudesai, Patrick Essay, Edward J Bedrick, Jacqueline C Stocking, Julia M Fisher   +7 more
doaj   +1 more source

New noninvasive modalities in long-term pediatric ventilation: a scoping review

Monaldi Archives for Chest Disease
Long-term noninvasive ventilation modalities for the pediatric population have undergone a continuous evolution. Hybrid noninvasive ventilation modalities have been recently introduced in clinical practice.
Martino Pavone, Giovanni Misseri, Mariachiara Ippolito, Cesare Gregoretti, Renato Cutrera   +4 more
doaj   +1 more source

Consecutive Emergency Carotid Artery Stenting and Transcatheter Aortic Valve Replacement in a Patient With Cardiogenic Shock: A Case Report

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Severe aortic stenosis (AS) carries a poor prognosis when symptomatic, particularly in cardiogenic shock (CS). Emergency transcatheter aortic valve replacement (TAVR) is rarely performed but may represent a rescue therapy. Coexistent carotid artery stenosis (CAS) further increases procedural risk.
Max Groche, Claudio Silwanis, Clemens Steinwender, Thomas Lambert   +3 more
wiley   +1 more source

Advances in vital‐sign prediction and early‐warning models for underground coal mine workers integrating environmental factors

Deep Underground Science and Engineering, EarlyView.
This review synthesizes advances in predicting miners' vital signs by integrating environmental monitoring (dust, temperature, and gas) with physiological data. It highlights multi‐source data fusion techniques and early‐warning models for enhanced occupational safety in underground coal mines.
Junji Zhu, Dawei Cui, Yingjie Liu, Yuntao Liang, Yue Zhang   +4 more
wiley   +1 more source

Postoperative noninvasive ventilation

Zdravniški Vestnik, 2010
Backround: Patients with acute respiratory failure often require endotracheal intubation and mechanical ventilation. Non-invasive ventilation (NIV) means ventilation without an artificial airway – endotracheal tubus or tracheostomy canulla.
Lucija Oberauner, Ludovik Strauch, Ljudmila Sakelšek-Jeras, Ana Špec-Marn, Špela Štupnik-Pirtovšek   +4 more
doaj  

Non-invasive mechanical ventilation [PDF]

ABC: časopis urgentne medicine
Respiratory failure is one of the most common conditions that require urgent medical intervention and represents a major challenge for physicians. Given the importance of the respiratory system, rapid and adequate treatment is crucial for the patient's ...
Đuketić Nikola, Pašić Ana, Gavrilović Nikola, Jokšić-Mazinjanin Radojka   +3 more
doaj   +1 more source

Effect of epileptogenesis on hypercapnic cardioventilatory response in kainic acid rats

Epilepsia, EarlyView.
Abstract Objective Cardioventilatory failure is the leading mechanism proposed to underlie sudden unexpected death in epilepsy (SUDEP), which occurs predominantly at night in patients with generalized tonic–clonic seizures. Interictal hypercapnic cardioventilatory responses are suggested to be involved, as they are ablated in chronically epileptic ...
Auriane Apaire, Elise Collard, Abigail Niyibizi, Natasha N. Kumar, Enrique Germany Morrison, Javier Chavez Cerda, Ayse S. Dereli, Riem El Tahry   +7 more
wiley   +1 more source

Ventilação não invasiva em pediatria Noninvasive ventilation in pediatrics

Jornal de Pediatria, 2003
OBJETIVO: Apresentar a ventilação mecânica não invasiva em pediatria como uma alternativa à ventilação invasiva, mostrar suas vantagens e desvantagens, quando se encontra indicada e como instalá-la.
Dafne Cardoso Bourguignon da Silva, Flavia Andrea Krepel Foronda, Eduardo Juan Troster   +2 more
doaj   +1 more source