Results 31 to 40 of about 69,720 (262)

Piecewise continuous approach to nonlinear differential equations approximation problem of computational structural mechanics

MATEC Web of Conferences, 2018
This paper presents a nonlinear differential equations system piecewise continuous approximation. The piecewise continuous approximation improves piecewise linear approximation through reducing the errors at the boundaries of different linear ...
Leibov Roman
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Explicit Approximation Rates for Shallow Networks on Additive Besov Classes

Mathematics
We study the approximation of functions by localized shallow neural networks on bounded Lipschitz domains. For a non-polynomial activation, we establish a direct, Jackson-type estimate on the Besov scale Bp,qs(Ω), the approximation error decaying as N−s ...
Zhenliang Chen, Kai-Cheng Wang
doaj   +1 more source

A posteriori error estimates of spectral method for nonlinear parabolic optimal control problem

Journal of Inequalities and Applications, 2018
In this paper, we investigate the spectral approximation of optimal control problem governed by nonlinear parabolic equations. A spectral approximation scheme for the nonlinear parabolic optimal control problem is presented. We construct a fully discrete
Lin Li, Zuliang Lu, Wei Zhang, Fei Huang, Yin Yang   +4 more
doaj   +1 more source

Padé-Sumudu-Adomian Decomposition Method for Nonlinear Schrödinger Equation

Journal of Applied Mathematics, 2021
The main purpose of this paper is to solve the nonlinear Schrödinger equation using some suitable analytical and numerical methods such as Sumudu transform, Adomian Decomposition Method (ADM), and Padé approximation technique. In many literatures, we can
Metomou Richard, Weidong Zhao
doaj   +1 more source

Homogeneous Approximation of One- Dimensional Series of Iterated Integrals and Time Optimality

Journal of Optimization, Differential Equations and Their Applications, 2023
In the paper we consider nonlinear systems depending linearly on control with one-dimensional output. As is well known, under the analyticity requirement, the output can be expressed as a series of iterated integrals of controls with scalar coefficients.
Daria M. Andreieva, Svetlana Yu. Ignatovich   +1 more
doaj   +1 more source

Kernel Methods for the Approximation of Nonlinear Systems [PDF]

SIAM Journal on Control and Optimization, 2017
Rewritten to improve readability.
Jake V. Bouvrie, Boumediene Hamzi
openaire   +5 more sources

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

APPROXIMATE SOLUTIONS OF NONLINEAR OSCILLATORS

NWSA Academic Journals, 2017
The modified homotopy perturbation method (MHPM) is used for solving the differential equation of pendulum model. Comparisons are made between the standard HPM and the MHPM. The results show that this method is effective and can obtain high accuracy solutions by only one iteration.
openaire   +4 more sources