Results 41 to 50 of about 71,359 (311)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Wave Energy Dissipation of Spilling and Plunging Breaking Waves in Spectral Models
Journal of Marine Science and Engineering, 2022 On the basis of field experiments and modeling, the dependence of the dissipation of the energy of waves breaking by plunging and spilling on the frequency of wave spectra was investigated. It was shown that the modeling of wave breaking should take into
Yana Saprykina +2 more
doaj +1 more source
APPROXIMATE SOLUTIONS OF NONLINEAR OSCILLATORS
NWSA Academic Journals, 2017 The modified homotopy perturbation method (MHPM) is used for solving the differential equation of pendulum model. Comparisons are made between the standard HPM and the MHPM. The results show that this method is effective and can obtain high accuracy solutions by only one iteration.
openaire +4 more sources
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
MATEC Web of Conferences, 2017 This paper presents a bilinear approach to nonlinear differential equations system approximation problem. Sometimes the nonlinear differential equations right-hand sides linearization is extremely difficult or even impossible.
Leibov Roman
doaj +1 more source
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
NARX Deep Convolutional Fuzzy System for Modelling Nonlinear Dynamic Processes
Mathematics, 2023 This paper presents a new approach for modelling nonlinear dynamic processes (NDP). It is based on a nonlinear autoregressive with exogenous (NARX) inputs model structure and a deep convolutional fuzzy system (DCFS).
Marjan Golob
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FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Nonlinear compressive reduced basis approximation for PDE’s
Comptes Rendus. Mécanique, 2023 Linear model reduction techniques design offline low-dimensional subspaces that are tailored to the approximation of solutions to a parameterized partial differential equation, for the purpose of fast online numerical simulations.
Cohen, Albert +3 more
doaj +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source