Results 51 to 60 of about 166,893 (293)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

High-Field Nonlinear Terahertz Conductivities of Iron Ultrathin Films

Nanomaterials
The electronic transport behavior in ferromagnetic thin films critically dictates the functionality and efficiency of devices in spintronics and modern materials science.
Lewen Zhu, Zhiqiang Lan, Yingyu Guo, Danni Li, Lin Xi, Huiping Zhang, Zuanming Jin   +6 more
doaj   +1 more source

Sliding motion of a two-dimensional Wigner crystal in a strong magnetic field

, 1994
We study the sliding state of a two-dimensional Wigner crystal in a strong magnetic field and a random impurity potential. Using a high-velocity perturbation theory, we compute the nonlinear conductivity, various correlation functions, and the ...
A. C. Shi, A. I. Larkin, A. J. Millis, A. Schmid, B. G. A. Normand, C. E. Johnson, D. C. Tsui, D. S. Fisher, D. S. Fisher, F. I. B. Williams, G. Grüner, H. Buhmann, H. Fukuyama, H. Fukuyama, H. Fukuyama, H. Fukuyama, H. Matsukawa, H. W. Jiang, H. W. Jiang, H. W. Jiang, H. W. Jiang, J. M. Kosterlitz, L. Bonsall, L. Sneddon, L. Sneddon, M. B. Santos, M. B. Santos, M. D'Iorio, O. Viehweger, P. A. Lee, P. A. Lee, P. B. Littlewood, P. B. Littlewood, P. B. Littlewood, R. Coté, R. Coté, R. Price, S. C. Zhang, S. I. Dorozhkin, S. Kivelson, S. N. Coppersmith, S. N. Coppersmith, S. N. Coppersmith, T. M. Rice, T. Sajoto, V. J. Goldman, V. J. Goldman, V. M. Pudalov, X. J. Zhu, X. Zhu, Xuejun Zhu, Y. Imry, Y. P. Li   +52 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Weak Limits in Nonlinear Conductivity [PDF]

SIAM Journal on Mathematical Analysis, 2015
The problem of characterizing weak limits of sequences of solutions for a non-linear diffusion equation of $p$-laplacian type is addressed. It is formulated in terms of certain moments of underlying Young measures associated with main fields corresponding to the non-linear equation. We show two main results.
openaire   +2 more sources

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Heat conduction in 2d nonlinear lattices

, 1999
21 pages, 8 postscript ...
A. LIPPI, LIVI, ROBERTO
openaire   +3 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Unifying semiclassics and quantum perturbation theory at nonlinear order

SciPost Physics, 2023
Nonlinear electrical response permits a unique window into effects of band structure geometry. It can be calculated either starting from a Boltzmann approach for small frequencies, or using Kubo's formula for resonances at finite frequency.
Daniel Kaplan, Tobias Holder, Binghai Yan
doaj   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source