Results 51 to 60 of about 945,100 (334)

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

Design of a multivariable neural controller for control of a nonlinear MIMO plant

open access: yesInternational Journal of Applied Mathematics and Computer Science, 2014
The paper presents the training problem of a set of neural nets to obtain a (gain-scheduling, adaptive) multivariable neural controller for control of a nonlinear MIMO dynamic process represented by a mathematical model of Low-Frequency (LF) motions of a
Bańka Stanisław   +2 more
doaj   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

open access: yesMolecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha   +10 more
wiley   +1 more source

Nonlinear Control Systems Simulation Using Spreadsheets

open access: yesSpreadsheets in Education, 2004
In this paper, a method for simulating nonlinear control systems using spreadsheets is presented. Various nonlinear blocks are simulated using graphics and cell formulas, and are generated by clicking on specially developed toolbar buttons.
Ali El-Hajj   +2 more
doaj  

Event-triggered tracking control for switched nonlinear systems

open access: yesMathematical Biosciences and Engineering, 2023
In this paper, we study the output tracking control problem based on the event-triggered mechanism for cascade switched nonlinear systems. Firstly, an integral controller based on event-triggered conditions is designed, and the output tracking error of ...
Xiaoxiao Dong   +3 more
doaj   +1 more source

Controller performance design and assessment using nonlinear generalized minimum variance benchmark : scalar case [PDF]

open access: yes, 2004
A nonlinear version of the Generalized Minimum Variance (GMV) multivariable control law has been recently derived for the control of nonlinear, possibly time-varying systems.
Grimble, M.J., Majecki, P.M.
core  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Cooperative Passivity-Based Control of Nonlinear Mechanical Systems

open access: yesRobotics, 2023
In this work, we propose two cooperative passivity-based control methods for networks of mechanical systems. By cooperatively synchronizing the end-effector coordinates of the individual agents, we achieve cooperation between systems of different types ...
Oscar de Groot   +2 more
doaj   +1 more source

H∞ control of nonlinear systems: a convex characterization [PDF]

open access: yes, 1993
The nonlinear H∞-control problem is considered with an emphasis on developing machinery with promising computational properties. The solutions to H∞-control problems for a class of nonlinear systems are characterized in terms of nonlinear matrix ...
Doyle, John C., Lu, Wei-Min
core   +3 more sources

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

open access: yesFEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel   +9 more
wiley   +1 more source

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