Results 51 to 60 of about 254,556 (314)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Ascertaining when a basin is Wada: the merging method

open access: yesScientific Reports, 2018
Trying to imagine three regions separated by a unique boundary seems a difficult task. However, this is exactly what happens in many dynamical systems showing Wada basins.
Alvar Daza   +2 more
doaj   +1 more source

Study on the Inherent Complex Features and Chaos Control of IS–LM Fractional-Order Systems

open access: yesEntropy, 2016
Based on the traditional IS–LM economic theory, which shows the relationship between interest rates and output in the goods and services market and the money market in macroeconomic. We established a four-dimensional IS–LM model involving four variables.
Junhai Ma, Wenbo Ren, Xueli Zhan
doaj   +1 more source

Strain Rate Effect on Mechanical Properties of the 3D-Printed Metamaterial Foams With Tunable Negative Poisson’s Ratio

open access: yesFrontiers in Materials, 2021
As a kind of metamaterial, the negative Poisson’s ratio foams, which expand (shrink) in the transverse direction when stretched (compressed) in the longitudinal direction, have many potential applications in fields such as aerospace and mechanical and ...
Di Gao   +9 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Nonlinear Dynamics

open access: yesMathematics, 2022
This chapter applies fundamental concepts of dynamics, nonlinearity, and chaotic behavior to notions of creativity, health, and illness. It describes how nonlinear dynamical systems (NDS) models apply to crucial issues and phenomena that are not well described with customary linear models.
António Lopes, J. Tenreiro Machado
openaire   +3 more sources

Some reflections on past and future of nonlinear dynamics in Economics and Finance

open access: yes, 2018
This paper offers an overview of the literature on the economic and financial applications of theory of nonlinear dynamics, especially bifurcation theory.
Anufriev, M   +8 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Microscale velocity-dependent unbinding generates a macroscale performance-efficiency tradeoff in actomyosin systems

open access: yesCommunications Biology
Myosin motors are fundamental biological actuators that power diverse mechanical tasks in eukaryotic cells via ATP hydrolysis. Previous work has linked myosin’s velocity-dependent detachment rate to macroscopic scale muscle dynamics described by Hill’s ...
Jake McGrath   +3 more
doaj   +1 more source

Symmetry in Nonlinear Dynamics and Chaos

open access: yesSymmetry, 2022
Nonlinear dynamics and chaos have collaborated to increase our understanding of several phenomena [...]
openaire   +2 more sources

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