Results 61 to 70 of about 398,053 (318)
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Topics in Linear and Nonlinear Dispersive Waves [PDF]
, 1976 The various singularities and instabilities which arise in the modulation theory of dispersive wavetrains are studied. Primary interest is in the theory of nonlinear waves, but a study of associated questions in linear theory provides background ...
Miklovic, Donald W.
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Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
ChemistryEuropeThe first report on enantioselective zinc‐catalyzed aldehyde alkylation mediated by a chiral auxiliary has been revisited in the context of recent advances in the field.
Joseph El Khoury +3 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel +8 more
wiley +1 more source
Damping System Designs using Nonlinear Frequency Analysis Approach [PDF]
, 2012 The main purpose of this thesis focuses on the investigation of the frequency domain analysis and design approaches for nonlinear damping systems. With the development of modern mechanical and civil engineering structures, the vibration control has ...
Guo, Pengfei
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Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher +10 more
wiley +1 more source
Non-Linear Relationship between Macroeconomic Variables and Government Size in Iran [PDF]
فصلنامه پژوهشهای اقتصادی ایران, 2018 Attitude towards the role of government and reasons for the existence of government have experienced several changes and revisions during the last century.
Hassan Heidari, Arash Refah-Kahriz
doaj +1 more source
, 2022 In this study, a unified nonlinear dynamic buckling analysis for Euler–Bernoulli beam–columns subjected to constant loading rates is proposed with the incorporation of mercurial damping effects under thermal environment.
Gao, K, Song, C, Gao, W, Wu, D
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Arthritis Care &Research, EarlyView.Objective We assessed the effectiveness of PrismRA to improve clinical outcomes among patients with rheumatoid arthritis (RA) initiating treatment with a biologic or targeted synthetic disease‐modifying antirheumatic drug (b/tsDMARD). Methods PrismRA incorporated 19 gene expression features and four clinical features to assess a patient's likelihood of
Fenglong Xie +3 more
wiley +1 more source