Results 31 to 40 of about 1,055,018 (270)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Practical Ulam-Hyers-Rassias stability for nonlinear equations [PDF]

open access: yesMathematica Bohemica, 2017
In this paper, we offer a new stability concept, practical Ulam-Hyers-Rassias stability, for nonlinear equations in Banach spaces, which consists in a restriction of Ulam-Hyers-Rassias stability to bounded subsets.
Jin Rong Wang, Michal Fečkan
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

On discrete analogues of nonlinear implicit differential equations

open access: yesAdvances in Difference Equations, 2006
This paper deals with some classes of nonlinear implicit difference equations obtained via discretization of nonlinear differential-algebraic or partial differential-algebraic equations.
Anh Pham Ky, Loi Le Cong
doaj   +2 more sources

Multidimensional transonic shock waves and free boundary problems

open access: yesBulletin of Mathematical Sciences, 2022
We are concerned with free boundary problems arising from the analysis of multidimensional transonic shock waves for the Euler equations in compressible fluid dynamics.
Gui-Qiang G. Chen, Mikhail Feldman
doaj   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

open access: yesFEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang   +7 more
wiley   +1 more source

Improved ()-Expansion Method for the Space and Time Fractional Foam Drainage and KdV Equations

open access: yesAbstract and Applied Analysis, 2013
The fractional complex transformation is used to transform nonlinear partial differential equations to nonlinear ordinary differential equations. The improved ()-expansion method is suggested to solve the space and time fractional foam drainage and KdV ...
Ali Akgül   +2 more
doaj   +1 more source

Nonlinear Differential Equations Satisfied by Certain Classical Modular Forms

open access: yes, 2010
A unified treatment is given of low-weight modular forms on \Gamma_0(N), N=2,3,4, that have Eisenstein series representations. For each N, certain weight-1 forms are shown to satisfy a coupled system of nonlinear differential equations, which yields a ...
A. Enneper   +40 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

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