Results 41 to 50 of about 128,037 (313)

Free-Decay Nonlinear System Identification via Mass-Change Scheme

open access: yesShock and Vibration, 2019
Methods for nonlinear system identification of structures generally require input-output measured data to estimate the nonlinear model, as a consequence of the noninvariance of the FRFs in nonlinear systems.
Dario Anastasio, Stefano Marchesiello
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Identification of a nonlinear dynamic biological model using the dominant parameter selection method

open access: yes, 2010
The identification of nonlinear models sometimes encounters problems because of the limited amount of available measurements in combination with a large number of uncertain model parameters to be identified.
Gutman Per-O   +2 more
core   +1 more source

Identification of a Nonlinear Wheel/Rail Adhesion Model for Heavy-Duty Locomotives

open access: yesIEEE Access, 2018
The optimal wheel/rail adhesion of heavy-duty locomotives under traction must be determined given that suboptimal wheel/rail adhesion may result in low creep utilization, skidding, and idling.
Jing He   +4 more
doaj   +1 more source

Simultaneous Regression and Selection in Nonlinear Modal Model Identification

open access: yesVibration, 2021
High fidelity finite element (FE) models are widely used to simulate the dynamic responses of geometrically nonlinear structures. The high computational cost of running long time duration analyses, however, has made nonlinear reduced order models (ROMs ...
Christopher Van Damme   +3 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Quantitative robustness analysis of model following control for nonlinear systems subject to model uncertainties [PDF]

open access: yes, 2021
We investigate a model following control (MFC) design for nonlinear minimumphase systems subject to model uncertainties. The model following control architecture is a two degrees-of-freedom structure consisting of two control loops.
Willkomm, Julian   +2 more
core   +1 more source

Parameter identification of hysteresis nonlinear dynamic model for piezoelectric positioning system based on the improved particle swarm optimization method

open access: yesAdvances in Mechanical Engineering, 2017
An improved particle swarm optimization method that has better equilibrium characteristic between global search and local search is proposed for parameter identification of hysteresis nonlinear dynamic model for piezoelectric positioning system.
Yu Xie, Jing-Li Fu, Ben-Yong Chen
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Online identification and nonlinear control of the electrically stimulated quadriceps muscle [PDF]

open access: yes, 2005
A new approach for estimating nonlinear models of the electrically stimulated quadriceps muscle group under nonisometric conditions is investigated. The model can be used for designing controlled neuro-prostheses. In order to identify the muscle dynamics
Fraser, M.   +13 more
core   +1 more source

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