Results 41 to 50 of about 63,859 (262)

A smooth gain scheduling generalized predictive control

ENP Engineering Science Journal
Nonlinear model predictive control is an emerging control technique dealing with high nonlinearities of industrial plants. However, it suffers from many hurdles such as the numerical problems related to the resulting no convex nonlinear optimization ...
Yassine Himour, Mohamed Tadjine, Mohamed-Seghir Boucherit   +2 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Non-linear model predictive control for variable speed hydropower

Scientific Reports
Inverter Based Resources (IBR) are gaining more popularity in modern power systems, leading to decrease in grid inertia. Hydropower Plants with rotating synchronous machines have been excellent source of inertia in existing grids.
Tajana Nepal, Tommy Sneltvedt, Choukha Ram, Diwakar Bista, Thomas Øyvang, Roshan Sharma   +5 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Optimisation of a Gas-Lifted System with Nonlinear Model Predictive Control

Energies, 2023
A gas-lifted system in a mature oil well can experience casing-heading instability, which reduces the mean oil production and it is not healthy for the downstream equipment.
Ojonugwa Adukwu, Darci Odloak, Fuad Kassab   +2 more
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Fuzzy model predictive control for nonlinear processes [PDF]

Proceedings of 2012 IEEE 17th International Conference on Emerging Technologies & Factory Automation (ETFA 2012), 2012
The paper proposes an adaptive fuzzy predictive control method for industrial processes, which is based on the Generalized predictive control (GPC) algorithm. To provide good accuracy in the identification of unknown nonlinear plants, an online adaptive law is proposed to adapt a T-S fuzzy model.
Jérôme Mendes, Rui Araújo
openaire   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Practical Nonlinear Model Predictive Control With Kolmogorov–Arnold Network Models

IEEE Access
This paper presents a novel approach to practical nonlinear model predictive control (PNMPC) using Kolmogorov–Arnold networks (KANs) as prediction models.
Bernardo Barancelli Schwedersky, Rodolfo Cesar Costa Flesch   +1 more
doaj   +1 more source