Results 31 to 40 of about 57,687 (265)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Geometrically Nonlinear Static Analysis of High-Aspect-Ratio Truss-Braced Wing
Engineering ProceedingsTruss-braced wings (TBWs) feature higher aspect ratios with a lighter weight and lower bending moment than conventional wings. These wings show significant potential for performance improvements in terms of fuel efficiency.
Yanxin Huang, Jinchi Chen, Qingyuan Ma
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Non-Linear Static Analysis of Masonry Buildings under Seismic Actions [PDF]
Journal of Systemics, Cybernetics and Informatics, 2018 Assessing existing masonry buildings in seismic zones is a critical issue, due to the high vulnerability of the built environment. Commonly, beside local analysis, refined assessment procedures are used based on non-linear static methods, like the ...
Maria Luisa Beconcini +5 more
doaj
A Numerical-Experimental Method for Drop Impact Analysis of Composite Landing Gear
Shock and Vibration, 2017 The special material performance, manufacturing process, machining behavior, and operating condition of composite materials cause uncertainties to inevitably appear in the mechanical properties of composite structures.
Yongliang Guan +3 more
doaj +1 more source
Nonlinear Seismic Performance of RC Structures with Different Floor by Capacity Spectrum Method [PDF]
Journal of Structural and Construction Engineering, 2019 Civil engineering structures as well as office or apartment building are affected by earthquakes. In some buildings, few or no walls are provided at the first story (pilot).
علی کارگران, Ali Kheyroddin
doaj +1 more source
Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley +1 more source
Archives of Civil Engineering, 2012 The goal of this work is to compare different constitutive models in the nonlinear static characteristic analysis of asphalt concrete core dams. The Duncan E- μ model, Duncan E-B model and double-yield-surface model are three major constitutive models in
Hong Z., Hongyan Z., Jianke D.
doaj +1 more source
A Nonlinear Static Procedure for the Seismic Design of Symmetrical Irregular Bridges
Shock and Vibration, 2020 Displacement-based seismic design methods support the performance-based seismic design philosophy known to be the most advanced seismic design theory. This paper explores one common type of irregular-continuous bridges and studies the prediction of their
Shanshan Li +4 more
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Progressive collapse scenario in steel structures with irregularity in height
Građevinar, 2021 the overload caused by removal of these elements can cause damage and Progressive Collapse (PC) in structures. Therefore, the effect of sudden column removal and structural capacity against PC scenarios in medium and high-rise buildings is investigated ...
Ali Esfandiari Fard +2 more
doaj +1 more source