Results 21 to 30 of about 355,230 (269)

Carbon market price prediction in the Yangtze River Basin based on improved deep learning ensemble model with CEEMDAN and Attention-RNN

Carbon Balance and Management
Accurate carbon price prediction can help the government establish an effective and stable carbon trading market mechanism, which researchers are increasingly focusing on.
Zuliang Lu, Zhihui Cao, Zhuran Xiang, Junman Li, Mingsong Li   +4 more
doaj   +1 more source

The research of river basin ecological compensation based on water emissions trading mechanism

Water Science and Technology
By integrating the successful case of the European Union emissions trading system, this study proposes a water emissions trading system, a novel method of reducing water pollution.
Zuliang Lu, Lu Xing, Ruixiang Xu, Chunjuan Hou, Yin Yang   +4 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Tricomi Problem for a Second-Kind Mixed-Type Equation in a Domain Whose Elliptic Part Is a Vertical Half-Strip

Mathematics
In this paper, the Tricomi problem for a second-kind mixed-type equation with a lower-order term is studied in an unbounded domain. The elliptic part of the domain is a vertical half-strip, while the hyperbolic part is bounded by characteristics ...
Rakhimjon Zunnunov, Roman Parovik, Anvar Khudayorov   +2 more
doaj   +1 more source

Pattern-Moving-Based Partial Form Dynamic Linearization Model Free Adaptive Control for a Class of Nonlinear Systems

Actuators, 2021
This work addresses a pattern-moving-based partial form dynamic linearization model free adaptive control (P-PFDL-MFAC) scheme and illustrates the bounded convergence of its tracking error for a class of unknown nonaffine nonlinear discrete-time systems.
Xiangquan Li, Zhengguang Xu
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Observer Design for Nonlinear Descriptor Systems: A Survey on System Nonlinearities

Circuits, Systems, and Signal Processing
AbstractIn general, the construction of observers for nonlinear descriptor systems depends on the solvability of a linear matrix inequality involving system matrices, and it is based on the system’s nonlinearity. Therefore, the type of nonlinearity present in the system heavily affects the observer design process.
Meenakshi Tripathi, Lazaros Moysis, Mahendra Kumar Gupta, George F. Fragulis, Christos K. Volos   +4 more
openaire   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source