Results 41 to 50 of about 350,611 (269)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Resonantly enhanced second- and third-harmonic generation in dielectric nonlinear metasurfaces

Opto-Electronic Advances
Nonlinear dielectric metasurfaces provide a promising approach to control and manipulate frequency conversion optical processes at the nanoscale, thus facilitating both advances in fundamental research and the development of new practical applications in
Ji Tong Wang, Pavel Tonkaev, Kirill Koshelev, Fangxing Lai, Sergey Kruk, Qinghai Song, Yuri Kivshar, Nicolae C. Panoiu   +7 more
doaj   +1 more source

Stabilisation strategy based on feedback linearisation for DC microgrid with multi-converter

The Journal of Engineering, 2019
Power electronic converters have been widely used in power system and the stability issues of DC microgrid with converters will be discussed in this study. Firstly, an equivalent circuit and the corresponding state space model for DC microgrid with DC–DC
Xuanying Shao, Jian Hu, Zhongtian Zhao
doaj   +1 more source

A Robust State Estimator for T-S Fuzzy System

IEEE Access, 2020
In this paper, a robust filter is derived to estimate the state of a nonlinear system which is described by T-S fuzzy model. Firstly, this paper studies a robust state estimation algorithm based on the relationship between Kalman filter and regularized ...
Ziqiang Li, Jing Wang, Huabo Liu
doaj   +1 more source

Factorization of Nonlinear Systems [PDF]

, 1989
Summary: A basic result of \textit{H. Bart}, \textit{I. Gohberg} and \textit{M. A. Kaashoek} [Minimal factorization of matrix and operator functions (1979; Zbl 0424.47001)] parametrizes factorizations of the transfer function of a linear system in terms of the state space equations of the system. This paper extends their result to nonlinear systems.
openaire   +2 more sources

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

Study of Super-Twisting sliding mode control for U model based nonlinear system

Journal of Hebei University of Science and Technology, 2016
The Super-Twisting control algorithm is adopted to analyze the U model based nonlinear control system in order to solve the controller design problems of non-affine nonlinear systems.
Jianhua ZHANG, Yang LI, Xueli WU, Jianan HUO, Shenyang ZHUANG   +4 more
doaj   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Use of a Molecular Signature Response Classifier to Inform Treatment Selection Improves Clinical Disease Activity Among Patients with Rheumatoid Arthritis Initiating a Biologic or Targeted Synthetic Disease‐Modifying Antirheumatic Drug

Arthritis Care &Research, EarlyView.
Objective We assessed the effectiveness of PrismRA to improve clinical outcomes among patients with rheumatoid arthritis (RA) initiating treatment with a biologic or targeted synthetic disease‐modifying antirheumatic drug (b/tsDMARD). Methods PrismRA incorporated 19 gene expression features and four clinical features to assess a patient's likelihood of
Fenglong Xie, Timothy Beukelman, Nicholas P. McCormick, Jeffrey R. Curtis   +3 more
wiley   +1 more source

Firefly algorithm based WSN-IoT security enhancement with machine learning for intrusion detection

Scientific Reports
A Wireless Sensor Network (WSN) aided by the Internet of Things (IoT) is a collaborative system of WSN systems and IoT networks are work to exchange, gather, and handle data.
M. Karthikeyan, D. Manimegalai, Karthikeyan RajaGopal   +2 more
doaj   +1 more source