Results 41 to 50 of about 427,822 (290)
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Advances in Mathematical Physics, 2016 It is proved that the modified Boussinesq equation is consistent Riccati expansion (CRE) solvable; two types of special soliton-cnoidal wave interaction solution of the equation are explicitly given, which is difficult to be found by other traditional ...
Wenguang Cheng, Biao Li
doaj +1 more source
Molecular Oncology, EarlyView.There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes +20 more
wiley +1 more source
Axioms, 2021 Heat exchangers are commonly used in various industries. A spiral-plate heat exchanger with two fluids is a compact plant that only requires a small space and is excellent in high heat transfer efficiency.
Guanqiang Dong, Mingcong Deng
doaj +1 more source
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
IEEE Access, 2022 We consider second order nonlinear systems in control canonical form, where the functional relation between the control variable and the system acceleration is nonlinear, uncertain and discontinuous.
Denis Vasko, Jan Kardos, Eva Miklovicova
doaj +1 more source
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
Simple Sliding Mode Controller with Adaptive Fuzzy Saturation Function for Nonlinear Single Input-Single Output System [PDF]
Engineering and Technology Journal, 2010 Sliding mode control algorithm that uses fuzzy saturation function is designed inthis paper for nonlinear system. The fuzzy saturation function is suggested to improvethe accuracy and the robustness of the sliding mode control which are partially ...
Hanady A. Jaber +2 more
doaj +1 more source
Theory of nonlinear systems [PDF]
Journal of the Franklin Institute, 1983 Abstract This paper gives a general review of the Theory of Nonlinear Systems. In 1960, the author presented a paper “Theory of Nonlinear Control” at the First IFAC Congress at Moscow. Professor Norbert Wiener, who attended this Congress, drew attention to his work on the synthesis and analysis of nonlinear systems in terms of Hermitian polynomials ...
openaire +3 more sources