Results 51 to 60 of about 427,822 (290)

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Total-Amount Synchronous Control Based on Terminal Sliding-Mode Control

IEEE Access, 2017
This paper presents a total-amount synchronous control (TASC) strategy for nonlinear systems with uncertainty based on finite-time control theory. In combination with a new type of terminal sliding-mode control strategy, finite-time convergence of TASC ...
Changfan Zhang, Zhenzhen Lin, Simon X. Yang, Jing He   +3 more
doaj   +1 more source

Noise Analysis and Modulation Optimization for Nonlinear Visible Light Communication System With Signal-Dependent Noise

IEEE Photonics Journal, 2023
This article investigates the characteristics of the signal-dependent noise (SDN) and corresponding modulation design in nonlinear visible light communication (VLC) systems.
Jiaqi Wei, Yuan Wang, Chen Gong, Nuo Huang   +3 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Nonlinear Vibration Analysis of Turbocharger Rotor Supported on Rolling Bearing by Modified Incremental Harmonic Balance Method

Machines
High-speed rolling bearings exhibit low friction, high mechanical efficiency, low lubrication requirements, and excellent acceleration performance. The replacement of floating ring bearings in turbochargers with rolling bearings is an important tendency ...
Tangwei Li, Hulun Guo, Zhenyu Cheng, Rixiu Men, Jun Li, Yushu Chen   +5 more
doaj   +1 more source

Factorization of Nonlinear Systems [PDF]

, 1989
Summary: A basic result of \textit{H. Bart}, \textit{I. Gohberg} and \textit{M. A. Kaashoek} [Minimal factorization of matrix and operator functions (1979; Zbl 0424.47001)] parametrizes factorizations of the transfer function of a linear system in terms of the state space equations of the system. This paper extends their result to nonlinear systems.
openaire   +3 more sources

The influence of ROS1 fusion partners and resistance mechanisms in ROS1‐TKI‐treated non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the
Fenneke Zwierenga, Christa Dijkhuizen, Patrick Korthuis, Wim Timens, Harry Groen, Jeroen Hiltermann, Anke van den Berg, Lyndsay Drayer, Anthonie van der Wekken   +8 more
wiley   +1 more source

Integral sliding mode control for non-linear systems with mismatched uncertainty based on quadratic sliding mode

The Journal of Engineering, 2015
In this study, uncertainty and disturbance compensations are addressed for non-linear systems by an integral sliding mode (ISM) design. It is divided into two steps for implementation of the ISM control.
Xiaoyu Zhang
doaj   +1 more source

The equivalent nonlinearity for a nonlinear system with dither

Journal of Mathematical Analysis and Applications, 1973
AbstractGiven a single loop nonlinear control system. The problem of constructing a dither signal in order to obtain a desired equivalent nonlinearity is considered. It is assumed that the nonlinearity may be described by a kth order polynomial. For this case it is shown that in general k different levels for the dither signal are necessary.
openaire   +3 more sources

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source