Results 31 to 40 of about 251,636 (269)
Jamming by compressing a system of granular crosses
EPJ Web of Conferences, 2017 A disordered stress-free granular packing can be jammed, transformed into a mechanically rigid structure, by increasing the density of particles or by applying shear deformation.
Zheng Hu +3 more
doaj +1 more source
Complexity of cortical wave patterns of the wake mouse cortex
Nature Communications, 2023 The cerebral cortex has ongoing electrical activities with rich and complex patterns in space and time. Here, the authors use optical voltage imaging in mice and computational methods, relating these complexities to different levels of wakefulness.
Yuqi Liang +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Lagrangian simulation and tracking of the mesoscale eddies contaminated by Fukushima-derived radionuclides [PDF]
Ocean Science, 2017 A Lagrangian methodology is developed to simulate, track, document and analyze the origin and history of water masses in ocean mesoscale features.
S. V. Prants +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Pulling an intruder from a granular material: a novel depinning experiment
EPJ Web of Conferences, 2017 Two-dimensional impact experiments by Clark et al. [2] identified the source of inertial drag to be caused by ‘collisions’ with a latent force network, leading to large fluctuations of the force experienced by the impactor.
Zhang Yue, Behringer Robert
doaj +1 more source
Gamma Oscillations Facilitate Effective Learning in Excitatory-Inhibitory Balanced Neural Circuits
Neural Plasticity, 2021 Gamma oscillation in neural circuits is believed to associate with effective learning in the brain, while the underlying mechanism is unclear. This paper aims to study how spike-timing-dependent plasticity (STDP), a typical mechanism of learning, with ...
Kwan Tung Li +2 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Mathematics, 2021 A computational framework for the construction of solutions to linear homogenous partial differential equations (PDEs) with variable coefficients is developed in this paper.
Zenonas Navickas +4 more
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source