Results 41 to 50 of about 1,450,845 (279)

Gamma Oscillations Facilitate Effective Learning in Excitatory-Inhibitory Balanced Neural Circuits

Neural Plasticity, 2021
Gamma oscillation in neural circuits is believed to associate with effective learning in the brain, while the underlying mechanism is unclear. This paper aims to study how spike-timing-dependent plasticity (STDP), a typical mechanism of learning, with ...
Kwan Tung Li, Junhao Liang, Changsong Zhou   +2 more
doaj   +1 more source

F-Operators for the Construction of Closed Form Solutions to Linear Homogenous PDEs with Variable Coefficients

Mathematics, 2021
A computational framework for the construction of solutions to linear homogenous partial differential equations (PDEs) with variable coefficients is developed in this paper.
Zenonas Navickas, Tadas Telksnys, Romas Marcinkevicius, Maosen Cao, Minvydas Ragulskis   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

A New Fractional-Order Map with Infinite Number of Equilibria and Its Encryption Application

Complexity, 2022
The study of the chaotic dynamics in fractional-order discrete-time systems has received great attention over the last years. Some efforts have been also devoted to analyze fractional maps with special features.
Ahlem Gasri, Amina-Aicha Khennaoui, Adel Ouannas, Giuseppe Grassi, Apostolos Iatropoulos, Lazaros Moysis, Christos Volos   +6 more
doaj   +1 more source

Empirical Model Reduction of Controlled Nonlinear Systems [PDF]

, 1999
In this paper we introduce a new method of model reduction for nonlinear systems with inputs and outputs. The method requires only standard matrix computations, and when applied to linear systems results in the usual balanced truncation. For nonlinear
Glavaški, Sonja, Lall, Sanjay, Marsden, Jerrold E.   +2 more
core   +3 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

The parametric characteristics of frequency response functions for nonlinear systems [PDF]

, 2006
The characteristics of the frequency response functions of nonlinear systems can be revealed and analyzed through the analysis of the parametric characteristics of these functions.
Billings, S.A., Jing, X.J., Lang, Z.Q., Tomlinson, G.R.   +3 more
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Some results on stability of difference systems

Discrete Dynamics in Nature and Society, 2002
This paper presents some new results on existence and stability of equilibrium or periodic points for difference systems. First sufficient conditions of existence of asymptotically stable equilibrium point as well as the asymptotic stability of given ...
Xiao-Song Yang, Ping Zhou
doaj   +1 more source