Results 51 to 60 of about 9,922,765 (307)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Nonsquare Spectral Factorization for Nonlinear Control Systems [PDF]

, 2005
This paper considers nonsquare spectral factorization of nonlinear input affine state space systems in continuous time. More specifically, we obtain a parametrization of nonsquare spectral factors in terms of invariant Lagrangian submanifolds and ...
Schaft, Arjan J. van der, Petersen, Mark A., Schaft, Arjan J. van der,, Schaft, Arjan J. van der; id_orcid, Petersen, Mark A.,   +4 more
core   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Pulling an intruder from a granular material: a novel depinning experiment

EPJ Web of Conferences, 2017
Two-dimensional impact experiments by Clark et al. [2] identified the source of inertial drag to be caused by ‘collisions’ with a latent force network, leading to large fluctuations of the force experienced by the impactor.
Zhang Yue, Behringer Robert
doaj   +1 more source

Gamma Oscillations Facilitate Effective Learning in Excitatory-Inhibitory Balanced Neural Circuits

Neural Plasticity, 2021
Gamma oscillation in neural circuits is believed to associate with effective learning in the brain, while the underlying mechanism is unclear. This paper aims to study how spike-timing-dependent plasticity (STDP), a typical mechanism of learning, with ...
Kwan Tung Li, Junhao Liang, Changsong Zhou   +2 more
doaj   +1 more source

Nonlinear cross Gramians and gradient systems [PDF]

, 2007
We study the notion of cross Gramians for non-linear gradient systems, using the characterization in terms of prolongation and gradient extension associated to the system.
Jacquelien M. A. Scherpen, Ionescu, T. C.,, Scherpen, J. M. A., Ionescu, T. C., Tudor C. Ionescu, Scherpen, J. M. A.,   +5 more
core   +2 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Lagrangian simulation and tracking of the mesoscale eddies contaminated by Fukushima-derived radionuclides [PDF]

Ocean Science, 2017
A Lagrangian methodology is developed to simulate, track, document and analyze the origin and history of water masses in ocean mesoscale features.
S. V. Prants, M. V. Budyansky, M. Y. Uleysky   +2 more
doaj   +1 more source

F-Operators for the Construction of Closed Form Solutions to Linear Homogenous PDEs with Variable Coefficients

Mathematics, 2021
A computational framework for the construction of solutions to linear homogenous partial differential equations (PDEs) with variable coefficients is developed in this paper.
Zenonas Navickas, Tadas Telksnys, Romas Marcinkevicius, Maosen Cao, Minvydas Ragulskis   +4 more
doaj   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source