Results 61 to 70 of about 2,173,723 (357)

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Pulling an intruder from a granular material: a novel depinning experiment

EPJ Web of Conferences, 2017
Two-dimensional impact experiments by Clark et al. [2] identified the source of inertial drag to be caused by ‘collisions’ with a latent force network, leading to large fluctuations of the force experienced by the impactor.
Zhang Yue, Behringer Robert
doaj   +1 more source

Gamma Oscillations Facilitate Effective Learning in Excitatory-Inhibitory Balanced Neural Circuits

Neural Plasticity, 2021
Gamma oscillation in neural circuits is believed to associate with effective learning in the brain, while the underlying mechanism is unclear. This paper aims to study how spike-timing-dependent plasticity (STDP), a typical mechanism of learning, with ...
Kwan Tung Li, Junhao Liang, Changsong Zhou   +2 more
doaj   +1 more source

Exact analytical soliton solutions of $N$-component coupled nonlinear Schrödinger equations with arbitrary nonlinear parameters [PDF]

arXiv, 2022
Exact analytical soliton solutions play an important role in soliton fields. Soliton solutions were obtained with some special constraints on the nonlinear parameters in nonlinear coupled systems, but they usually do not holds in real physical systems.
arxiv  

Resonances and resonant frequencies for a class of nonlinear systems [PDF]

, 2006
Resonant phenomena for a class of nonlinear systems, which can be described by a SDOF model with a polynomial type nonlinear stiffness, are investigated using Nonlinear Output Frequency Response Functions (NOFRFs).
Billings, S.A., Lang, Z.Q., Peng, Z.K.
core  

Linearization and input-output decoupling for general nonlinear systems [PDF]

, 1984
Necessary and sufficient conditions are obtained for the linearization and input decoupling (by state feedback) of general nonlinear systems. It is shown how these conditions can be derived from the already known conditions for affine nonlinear systems ...
Schaft, A.J. van der
core   +4 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Making Nonlinear Systems Negative Imaginary via State Feedback [PDF]

arXiv, 2022
This paper provides a state feedback stabilization approach for nonlinear systems of relative degree less than or equal to two by rendering them nonlinear negative imaginary (NI) systems. Conditions are provided under which a nonlinear system can be made a nonlinear NI system or a nonlinear output strictly negative imaginary (OSNI) system.
arxiv  

Global reconstruction of nonlinear systems from families of linear systems [PDF]

, 2002
This note concerns a fundamental issue in the modelling and realisation of nonlinear systems; namely, whether it is possible to uniquely reconstruct a nonlinear system from a suitable collection of transfer functions and, if so, under what conditions. It
Leith, D.J., Leithead, W.E.
core   +2 more sources

Controllability in nonlinear systems

Journal of Differential Equations, 1973
AbstractIn this paper we obtain an explicit expression for the reachable set for a class of nonlinear systems. This class is described by a chain condition on the Lie algebra of vector fields associated with each nonlinear system. These ideas are used to obtain a generalization of a controllability result for linear systems in the case where ...
openaire   +2 more sources