Results 41 to 50 of about 447,237 (298)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Evaluating Seismic Isolation Design: Simplified Linear Methods vs. Nonlinear Time-History Analysis

Designs
Seismic isolation is a vital strategy for improving the earthquake resilience of structures, utilizing flexible components such as lead–rubber bearings (LRBs) and curved surface sliders (CSSs) to attenuate ground motion effects.
Elias Yaacoub, Roberto Nascimbene, Marco Furinghetti, Alberto Pavese   +3 more
doaj   +1 more source

A note on tsunamis: their generation and propagation in an ocean of uniform depth [PDF]

, 1973
The waves generated in a two-dimensional fluid domain of infinite lateral extent and uniform depth by a deformation of the bounding solid boundary are investigated both theoretically and experimentally.
Hammack, Joseph L.
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Nonlinear Variable Parameter Time History Analysis on Dynamic Response of Timber Frame in Song Dynasty Palace

Taiyuan Ligong Daxue xuebao, 2021
In order to study the dynamic response of timber frame in Song Dynasty palace under horizontal acceleration, a series of nonlinear time-history analysis FE models were estallihed.
Jia WAN, Renfu GUO, Xiaochen MI, Jianwei WEI, Tieying LI   +4 more
doaj   +1 more source

Nonstationary Stochastic Simulation of Strong Ground-Motion Time Histories : Application to the Japanese Database [PDF]

, 2012
For earthquake-resistant design, engineering seismologists employ time-history analysis for nonlinear simulations. The nonstationary stochastic method previously developed by Pousse et al. (2006) has been updated.
Bonilla, Luis Fabian, Cotton, Fabrice, Laurendeau, Aurore   +2 more
core   +2 more sources

Damage detections in nonlinear vibrating thermally loaded plates [PDF]

, 2009
In this work, geometrically nonlinear vibrations of fully clamped rectangular plates subjected to thermal changesare used to study the sensitivity of some vibration response parameters to the presence of damage and elevated temperature. The geometrically
A.R. Kukreti, B.I. Epureanu, E. Manoach, E. Manoach, E. Manoach, E. Parloo, E.A Thorton, H.T. Banks, I. Trendafilova, I. Trendafilova, J. Cattarius, L. Moniz, M. Amabili, M. Todd, P. Ribeiro, P. Ribeiro, P. Verboven, P.F. Rizos, Y. Zou   +18 more
core   +2 more sources

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Rapid Seismic Evaluation of Continuous Girder Bridges with Localized Plastic Hinges

Sensors, 2022
In seismic assessment of continuous girder bridges, plastic hinges form in bridge piers to dissipate seismic energy through nonlinear restoring forces.
Zhaolan Wei, Mengting Lv, Minghui Shen, Haijun Wang, Qixuan You, Kai Hu, Shaomin Jia   +6 more
doaj   +1 more source

A hysteretic multiscale formulation for nonlinear dynamic analysis of composite materials [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.A new multiscale finite element formulation is presented for nonlinear dynamic analysis of heterogeneous structures.
A Chopra, AK Kaw, C Fuggini, C Hu, CT Herakovich, D Bournas, DR Cook, E. N. Chatzi, F Casadei, G Powell, GA Pavliotis, H Zhang, HM Hilber, HS Park, HW Zhang, HW Zhang, I Babuška, I Babuška, J Lubliner, J Lv, J Simo, J Simo, J Xu, JE Andrade, K Markov, K Washizu, K Worden, KJ Bathe, M Nithyadharan, M Tootkaboni, MM Aghdam, OC Zienkiewicz, OS Bursi, P Kanouté, P Sengupta, Q Yu, R Azizi, R Senthivel, RH Cherng, S Erlicher, S Erlicher, S Nemat-Naser, S. P. Triantafyllou, T Belytschko, T Zohdi, T Zohdi, TI Zohdi, TT Baber, TY Hou, VD Nguyen, WJ Harvey, X He, XF Xu, Y Efendiev, Y Efendiev, YR Kim   +55 more
core   +3 more sources