Results 51 to 60 of about 447,237 (298)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Evaluation of Advanced Nonlinear Static Procedure [PDF]

Journal of Structural and Construction Engineering, 2015
Having very simplicity, nonlinear static procedures (NSPs) are the most popular tools for estimation of structural capacity. These approaches construct a graphic display of the overall structural response via a pushover curve. The overall response of the
Mohsen Ali Shayanfar, Reza ZareBidoki
doaj  

The Comparison of the IDA and ET on Steel Structures Rehabilitated by Isolators [PDF]

Journal of Rehabilitation in Civil Engineering, 2014
Endurance time (ET) method is a relatively new performance-based earthquake method for structural evaluation and design. In this method, the structure is subjected to a gradually intensifying accelorogram(s) and its performance is assessed based on the ...
Hamed Arshadi, Ramezan Ali Izadifard, Homayun Estekanchi   +2 more
doaj   +1 more source

Robustness analysis of a nucleic acid controller for a dynamic biomolecular process using the structured singular value [PDF]

, 2019
In the field of synthetic biology, theoretical frameworks and software tools are now available that allow control systems represented as chemical reaction networks to be translated directly into nucleic acid-based chemistry, and hence implement embedded ...
Bates, Declan, Foo, Mathias, Kim, Jongmin, Paulino, Nuno   +3 more
core   +1 more source

Nonlinear Time-History Analysis of Soil-Structure Systems Incorporating Frequency-Dependent Impedance Functions

CoRR, 2023
To accurately analyze structures, soil-structure interaction effects must be taken into account. One approach is to create a complete finite element model of the full system wherein the soil is represented as a semi-infinite domain. This direct method is frequently adopted in research studies, but it is typically avoided in engineering practice due to ...
S. Farid Ghahari, Alborz Ghofrani, Jian Zhang 0041, Ertugrul Taciroglu   +3 more
openaire   +2 more sources

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Seismic Performance Evaluation of Multi-Storey Residential Building with Friction Pendulum Bearings: Indonesia case study

Structural Mechanics of Engineering Constructions and Buildings
The methodology for seismic performance evaluation of a residential building in Indonesia with the use of seismic isolation is considered. An 8-storey reinforced concrete frame residential building with shear wall structural system was selected as a case
Zaurbek K. Abaev, Faiz Sulthan
doaj   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

Effect of U-Shaped Metallic Dampers on the Seismic Performance of Steel Structures based on Endurance-Time Analysis

Buildings
Seismic performance of steel moment-resisting frames is investigated through the incorporation of U-shaped metallic dampers. The primary objective is to assess the effectiveness of these dampers in mitigating seismic responses by utilizing various ...
Farhad Farajiani, Farzaneh Elyasigorji, Sina Elyasigorji, Mohammad Javad Moradi, Visar Farhangi   +4 more
doaj   +1 more source

A quasi-static nonlinear analysis for assessing the fire resistance of 3d frames exploiting time-dependent yield surface [PDF]

, 2019
In this work an automatic procedure for evaluating the axial force-biaxial bending yield surface of reinforced concrete sections in fire is proposed. It provides an accurate time-dependent expression of the yield condition by a section analysis carried ...
de Gregorio, D., Garcea, G., Leonetti, L., Liguori, F., Magisano, D., Zuccaro, G.   +5 more
core