Results 31 to 40 of about 84,115 (259)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Assessment of Tension-Only Concentrically Braced Steel Frames in Relation to Seismic Pounding
Applied SciencesThis research examined the phenomenon of pounding between neighboring steel structures, both with and without tension-only braces, utilizing an extensive nonlinear time-history analysis.
Panagiota S. Katsimpini +2 more
doaj +1 more source
Rapid Seismic Evaluation of Continuous Girder Bridges with Localized Plastic Hinges
Sensors, 2022 In seismic assessment of continuous girder bridges, plastic hinges form in bridge piers to dissipate seismic energy through nonlinear restoring forces.
Zhaolan Wei +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Evaluating Seismic Isolation Design: Simplified Linear Methods vs. Nonlinear Time-History Analysis
DesignsSeismic isolation is a vital strategy for improving the earthquake resilience of structures, utilizing flexible components such as lead–rubber bearings (LRBs) and curved surface sliders (CSSs) to attenuate ground motion effects.
Elias Yaacoub +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Evaluation of Advanced Nonlinear Static Procedure [PDF]
Journal of Structural and Construction Engineering, 2015 Having very simplicity, nonlinear static procedures (NSPs) are the most popular tools for estimation of structural capacity. These approaches construct a graphic display of the overall structural response via a pushover curve. The overall response of the
Mohsen Ali Shayanfar, Reza ZareBidoki
doaj
The Comparison of the IDA and ET on Steel Structures Rehabilitated by Isolators [PDF]
Journal of Rehabilitation in Civil Engineering, 2014 Endurance time (ET) method is a relatively new performance-based earthquake method for structural evaluation and design. In this method, the structure is subjected to a gradually intensifying accelorogram(s) and its performance is assessed based on the ...
Hamed Arshadi +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source