Results 41 to 50 of about 447,237 (297)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Assessment of Tension-Only Concentrically Braced Steel Frames in Relation to Seismic Pounding

Applied Sciences
This research examined the phenomenon of pounding between neighboring steel structures, both with and without tension-only braces, utilizing an extensive nonlinear time-history analysis.
Panagiota S. Katsimpini, George A. Papagiannopoulos, George D. Hatzigeorgiou   +2 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Evaluating Seismic Isolation Design: Simplified Linear Methods vs. Nonlinear Time-History Analysis

Designs
Seismic isolation is a vital strategy for improving the earthquake resilience of structures, utilizing flexible components such as lead–rubber bearings (LRBs) and curved surface sliders (CSSs) to attenuate ground motion effects.
Elias Yaacoub, Roberto Nascimbene, Marco Furinghetti, Alberto Pavese   +3 more
doaj   +1 more source

Analisis Perilaku Struktur Beton dan Baja Dengan Metode Levelling Time History (Studi Kasus Gedung ITERA, Lampung, Indonesia)

Rekayasa Sipil, 2019
The selection of structural material types can be based on analyzing the behavioral of the structure by giving a nonlinear dynamic earthquake load of time history.
Ahmad Yudi, Bayzoni, Nugraha Bintang Wirawan, Rijuli Nadeak   +3 more
doaj   +1 more source

A note on tsunamis: their generation and propagation in an ocean of uniform depth [PDF]

, 1973
The waves generated in a two-dimensional fluid domain of infinite lateral extent and uniform depth by a deformation of the bounding solid boundary are investigated both theoretically and experimentally.
Hammack, Joseph L.
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

A case study on an innovative seismic performance evaluation procedure for irregular RC buildings

Frontiers in Built Environment, 2022
Assessing the structural capacity of an irregular structure requires an appropriate and robust representation of the analytical model. Conventional procedures are flawed because they lack the reversal effects of higher modes.
Resat A. Oyguc
doaj   +1 more source

Nonstationary Stochastic Simulation of Strong Ground-Motion Time Histories : Application to the Japanese Database [PDF]

, 2012
For earthquake-resistant design, engineering seismologists employ time-history analysis for nonlinear simulations. The nonstationary stochastic method previously developed by Pousse et al. (2006) has been updated.
Bonilla, Luis Fabian, Cotton, Fabrice, Laurendeau, Aurore   +2 more
core   +2 more sources

Damage detections in nonlinear vibrating thermally loaded plates [PDF]

, 2009
In this work, geometrically nonlinear vibrations of fully clamped rectangular plates subjected to thermal changesare used to study the sensitivity of some vibration response parameters to the presence of damage and elevated temperature. The geometrically
A.R. Kukreti, B.I. Epureanu, E. Manoach, E. Manoach, E. Manoach, E. Parloo, E.A Thorton, H.T. Banks, I. Trendafilova, I. Trendafilova, J. Cattarius, L. Moniz, M. Amabili, M. Todd, P. Ribeiro, P. Ribeiro, P. Verboven, P.F. Rizos, Y. Zou   +18 more
core   +2 more sources