Results 41 to 50 of about 88,298 (298)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Assessment of Tension-Only Concentrically Braced Steel Frames in Relation to Seismic Pounding

Applied Sciences
This research examined the phenomenon of pounding between neighboring steel structures, both with and without tension-only braces, utilizing an extensive nonlinear time-history analysis.
Panagiota S. Katsimpini, George A. Papagiannopoulos, George D. Hatzigeorgiou   +2 more
doaj   +1 more source

The Comparison of the IDA and ET on Steel Structures Rehabilitated by Isolators [PDF]

Journal of Rehabilitation in Civil Engineering, 2014
Endurance time (ET) method is a relatively new performance-based earthquake method for structural evaluation and design. In this method, the structure is subjected to a gradually intensifying accelorogram(s) and its performance is assessed based on the ...
Hamed Arshadi, Ramezan Ali Izadifard, Homayun Estekanchi   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Evaluating Seismic Isolation Design: Simplified Linear Methods vs. Nonlinear Time-History Analysis

Designs
Seismic isolation is a vital strategy for improving the earthquake resilience of structures, utilizing flexible components such as lead–rubber bearings (LRBs) and curved surface sliders (CSSs) to attenuate ground motion effects.
Elias Yaacoub, Roberto Nascimbene, Marco Furinghetti, Alberto Pavese   +3 more
doaj   +1 more source

supplemental_material – Supplemental material for An open-source framework for regional earthquakeloss estimation using thecity-scale nonlinear time history analysis

, 2020
Supplemental material, supplemental_material for An open-source framework for regional earthquakeloss estimation using thecity-scale nonlinear time history analysis by Xinzheng Lu, Frank McKenna, Qingle Cheng, Zhen Xu, Xiang Zeng and Stephen A Mahin in ...
Zhen Xu (92379), Xinzheng Lu (124452), Stephen A Mahin (8405604), Qingle Cheng (8405601), Frank McKenna (5726300), Xiang Zeng (664492)   +5 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Evaluation of Advanced Nonlinear Static Procedure [PDF]

Journal of Structural and Construction Engineering, 2015
Having very simplicity, nonlinear static procedures (NSPs) are the most popular tools for estimation of structural capacity. These approaches construct a graphic display of the overall structural response via a pushover curve. The overall response of the
Mohsen Ali Shayanfar, Reza ZareBidoki
doaj  

Analisis Perilaku Struktur Beton dan Baja Dengan Metode Levelling Time History (Studi Kasus Gedung ITERA, Lampung, Indonesia)

Rekayasa Sipil, 2019
The selection of structural material types can be based on analyzing the behavioral of the structure by giving a nonlinear dynamic earthquake load of time history.
Ahmad Yudi, Bayzoni, Nugraha Bintang Wirawan, Rijuli Nadeak   +3 more
doaj   +1 more source

A case study on an innovative seismic performance evaluation procedure for irregular RC buildings

Frontiers in Built Environment, 2022
Assessing the structural capacity of an irregular structure requires an appropriate and robust representation of the analytical model. Conventional procedures are flawed because they lack the reversal effects of higher modes.
Resat A. Oyguc
doaj   +1 more source