Results 61 to 70 of about 88,298 (298)

Nonlinear Response and Collapse Analysis of Double-Channel Aqueduct under Strong Earthquake

Advances in Civil Engineering, 2022
As a common water conveyance structure, aqueduct is widely used in cross-regional water conveyance and diversion projects. However, large double-trough aqueduct structures are prone to damage under earthquake, resulting in water leakage and even ...
Chong Wu, Jinpeng Zhang, Jianguo Xu, Chunyu Zhang, Yupeng Geng   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The effect of moment redistribution on the stability of reinforced concrete moment resisting frame buildings under the ground motion [PDF]

Journal of Structural and Construction Engineering, 2017
In recent years some studies have been done on the moment rredistribution in buildings and new methods offered for calculating of redistribution. Observations demonstrated that the combination of moment and shear force is important in analysis of ...
Mahdi Golpayegani, Alireza Mortezaei
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Extended Rayleigh Damping Model

Frontiers in Built Environment, 2016
In dynamic analysis, frequency domain analysis can be used if the entire structure is linear. However, time history analysis is generally used if nonlinear elements are present.
Naohiro Nakamura
doaj   +1 more source

Nonlinear time history analysis evaluation of optimized design for medium to high rise buildings using performance-based design

Ain Shams Engineering Journal, 2023
The performance-based design has been widely accepted as an alternative design method for designing and rehabilitating new and existing buildings. However, some codes and design guidelines do not allow this method to be implemented.
Haitham AbdelMalek, Tarek K. Hassan, Ayman Moustafa   +2 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

The Assessment and Comparison of Tall Buildings with Outrigger and Belt Truss Systems Using Fragility Curves [PDF]

Journal of Structural and Construction Engineering, 2018
In the design of high-rise buildings, three parameters such as resistance, hardness and stability are very important and when the height of building rises, effect of toughness and stability in optimum design will be dominate more than of the effects of ...
Hamed Hamidi, Jafar Pakdaman, Ehsan Jahani, Hamid Rajabnejad   +3 more
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source