Results 51 to 60 of about 447,237 (297)

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Evaluation of Advanced Nonlinear Static Procedure [PDF]

Journal of Structural and Construction Engineering, 2015
Having very simplicity, nonlinear static procedures (NSPs) are the most popular tools for estimation of structural capacity. These approaches construct a graphic display of the overall structural response via a pushover curve. The overall response of the
Mohsen Ali Shayanfar, Reza ZareBidoki
doaj  

Real-Time City-Scale Time-History Analysis and Its Application in Resilience-Oriented Earthquake Emergency Responses

Applied Sciences, 2019
The resilience of cities has received worldwide attention. An accurate and rapid assessment of seismic damage, economic loss, and post-event repair time can provide an important reference for emergency rescue and post-earthquake recovery.
Xinzheng Lu, Qingle Cheng, Zhen Xu, Yongjia Xu, Chujin Sun   +4 more
doaj   +1 more source

A hysteretic multiscale formulation for nonlinear dynamic analysis of composite materials [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.A new multiscale finite element formulation is presented for nonlinear dynamic analysis of heterogeneous structures.
A Chopra, AK Kaw, C Fuggini, C Hu, CT Herakovich, D Bournas, DR Cook, E. N. Chatzi, F Casadei, G Powell, GA Pavliotis, H Zhang, HM Hilber, HS Park, HW Zhang, HW Zhang, I Babuška, I Babuška, J Lubliner, J Lv, J Simo, J Simo, J Xu, JE Andrade, K Markov, K Washizu, K Worden, KJ Bathe, M Nithyadharan, M Tootkaboni, MM Aghdam, OC Zienkiewicz, OS Bursi, P Kanouté, P Sengupta, Q Yu, R Azizi, R Senthivel, RH Cherng, S Erlicher, S Erlicher, S Nemat-Naser, S. P. Triantafyllou, T Belytschko, T Zohdi, T Zohdi, TI Zohdi, TT Baber, TY Hou, VD Nguyen, WJ Harvey, X He, XF Xu, Y Efendiev, Y Efendiev, YR Kim   +55 more
core   +3 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Seismic Performance Evaluation of Multi-Storey Residential Building with Friction Pendulum Bearings: Indonesia case study

Structural Mechanics of Engineering Constructions and Buildings
The methodology for seismic performance evaluation of a residential building in Indonesia with the use of seismic isolation is considered. An 8-storey reinforced concrete frame residential building with shear wall structural system was selected as a case
Zaurbek K. Abaev, Faiz Sulthan
doaj   +1 more source

The Effect of Spandrel Beam's Specification on Response Modification Factor of Concrete Coupled Shear Walls [PDF]

Civil Engineering Infrastructures Journal, 2016
Response modification factor (R factor) is one of the seismic design parameters to be considered in evaluating the performance of buildings during strong motions. This paper has tried to evaluate the response modification factor of concrete coupled shear
Mussa Mahmoudi, seyed Mohammad Reza Mortazavi, Saeid Ajdari   +2 more
doaj   +1 more source

Robustness analysis of a nucleic acid controller for a dynamic biomolecular process using the structured singular value [PDF]

, 2019
In the field of synthetic biology, theoretical frameworks and software tools are now available that allow control systems represented as chemical reaction networks to be translated directly into nucleic acid-based chemistry, and hence implement embedded ...
Bates, Declan, Foo, Mathias, Kim, Jongmin, Paulino, Nuno   +3 more
core   +1 more source

Nonlinear Time-History Analysis of Soil-Structure Systems Incorporating Frequency-Dependent Impedance Functions

CoRR, 2023
To accurately analyze structures, soil-structure interaction effects must be taken into account. One approach is to create a complete finite element model of the full system wherein the soil is represented as a semi-infinite domain. This direct method is frequently adopted in research studies, but it is typically avoided in engineering practice due to ...
S. Farid Ghahari, Alborz Ghofrani, Jian Zhang 0041, Ertugrul Taciroglu   +3 more
openaire   +2 more sources

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source