Results 51 to 60 of about 40,313,599 (297)

Refined NSA approach for seismic assessment of regular RC frames

Građevinar, 2017
The nonlinear time-history analysis is often a time-consuming and impractical procedure. A new computer method, developed in the framework of the Eurocode 8 is proposed in this paper.
Szabolcs Varga, Cosmin G. Chiorean
doaj   +1 more source

Seismic displacement demand analyses for pile-supported wharves based on equivalent single-degree-of-freedom models

Shuili Shuiyun Gongcheng Xuebao, 2018
In the displacement-based seismic design method for the pile-supported wharves, the key is to determine seismic displacement demand accurately and reasonably.
GAO Shufei, FENG Yunfen, GONG Jinxin
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Chaos and Bifurcation Control Using Nonlinear Recursive Controller [PDF]

, 2002
Chaos and bifurcation control is achieved by nonlinear controller that is able to mitigate the characteristics of a class of nonlinear systems that are experiencing such phenomenon.
Zohdy, M. A., Harb, A. M.
core   +1 more source

Assessment of Tension-Only Concentrically Braced Steel Frames in Relation to Seismic Pounding

Applied Sciences
This research examined the phenomenon of pounding between neighboring steel structures, both with and without tension-only braces, utilizing an extensive nonlinear time-history analysis.
Panagiota S. Katsimpini, George A. Papagiannopoulos, George D. Hatzigeorgiou   +2 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Modeling nonlinear systems using multiple piecewise linear equations [PDF]

, 2010
This paper describes a technique for modeling nonlinear systems using multiple piecewise linear equations. The technique provides a means for linearizing the nonlinear system in such a way as to not limit the large signal behavior of the  ...
Lowe, G. K. K., Zohdy, M. A. A.
core   +1 more source

Rapid Seismic Evaluation of Continuous Girder Bridges with Localized Plastic Hinges

Sensors, 2022
In seismic assessment of continuous girder bridges, plastic hinges form in bridge piers to dissipate seismic energy through nonlinear restoring forces.
Zhaolan Wei, Mengting Lv, Minghui Shen, Haijun Wang, Qixuan You, Kai Hu, Shaomin Jia   +6 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Finite-time generalized synchronization of nonidentical delayed chaotic systems [PDF]

, 2016
This paper deals with the finite-time generalized synchronization (GS) problem of drive-response systems. The main purpose of this paper is to design suitable controllers to force the drive-response system realize GS in a finite time. Based on the finite-
Cao, Jinde, Bao, Haibo
core   +1 more source