Results 31 to 40 of about 71,838 (269)
Nonlinear DNA dynamics: Nonlinearity versus dispersion [PDF]
Applied Mathematics and Computation, 2013 In the present paper we study the impact of dispersion and nonlinearity on DNA dynamics. We rely on the helicoidal Peyrard-Bishop model and use the fact that nonlinear DNA dynamics represents an interplay between nonlinearity and dispersion. We state that a dispersion coefficient and a coefficient of nonlinearity, existing in nonlinear Schrödinger ...
Slobodan Zdravkovic, Miljko V. Sataric
openaire +3 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
L1 Adaptive Control for a Vertical Rotor Orientation System
Applied Sciences, 2016 Bottom-fixed vertical rotating devices are widely used in industrial and civilian fields. The free upside of the rotor will cause vibration and lead to noise and damage during operation.
Sijia Liu, Yu Fan, Jun Di, Mingming Ji
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Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Anais da Academia Brasileira de Ciências, 2001 The simultaneous propagation of two optical pulses through a doped nonlinear dispersive medium modelled by a resonant three-level system was investigated numerically, within the framework of a pair of coupled extended nonlinear Schrödinger equations ...
SOLANGE B. CAVALCANTI +3 more
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Nonlinear Pulse-Time Conversion in Radioisotope Devices: Analysis and Application Possibilities
Приборы и методы измерений, 2021 The paper considers the operation of radioisotope measuring devices under dynamic conditions, when the Poisson pulse flux at the output of the radiation detector becomes unsteady and the nonlinearity of the calibration curve of the device, the ...
A. M. Vodovozov
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Dose-response meta-analysis: application and practice using the R software [PDF]
Epidemiology and Health, 2019 The objective of this study was to describe the general approaches of dose-response meta-analysis (DRMA) available for the quantitative synthesis of data using the R software.
Sung Ryul Shim, Jonghoo Lee
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Frequency response areas in the inferior colliculus: nonlinearity and binaural interaction
Frontiers in Neural Circuits, 2013 The tuning, binaural properties, and encoding characteristics of neurons in the central nucleus of the inferior colliculus (CNIC) were investigated to shed light on nonlinearities in the responses of these neurons.
Jane J Yu, Eric Daniel Young
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