Results 51 to 60 of about 71,375 (269)
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
LandBuilding cycling-friendly street environments is crucial for promoting sustainable urban mobility. However, existing studies exploring the influence of the built environment on cycling have paid limited attention to the three-dimensional characteristics ...
Pengliang Hu +5 more
doaj +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
SIMULATION OF SYNCHRONIZATION OF NONLINEAR OSCILLATORS BY THE EXTERNAL FIELD
East European Journal of Physics, 2017 In this paper, the self-consistent model was considered, consisting of a system of oscillators, the coupling between them was assumed to be integral (due to the fields formed as a result of their co-radiation).
V. M. Kuklin +3 more
doaj
Principle of the overlay deformations in the theory of creep
Structural Mechanics of Engineering Constructions and Buildings, 2019 The aim of the research is to justify in the non-linear statement the overlay principle of fraction creep deformation, known in the linear creep theory as Bolzmann’s principle of superposition. Methods.
Evgeniy A. Larionov +2 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel +8 more
wiley +1 more source
Volterra Kernel Estimation of White Light LEDs in the Time Domain
Sensors, 2018 In this paper, we present a time domain method for extracting coefficients of nonlinear Volterra-series kernels for white light-emitting diodes (LED) used both for illumination and visible light communications.
Grzegorz Stepniak +2 more
doaj +1 more source
Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher +10 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Factors associated with relapse course and disability in myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) remain incompletely understood. Objectives To identify clinical and modifiable factors associated with relapse and disability in MOGAD. Methods In this ambispective multicentre cohort study using data from
Yingtao Wang +23 more
wiley +1 more source