Results 41 to 50 of about 173,390 (305)
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Anais da Academia Brasileira de Ciências, 2001 The simultaneous propagation of two optical pulses through a doped nonlinear dispersive medium modelled by a resonant three-level system was investigated numerically, within the framework of a pair of coupled extended nonlinear Schrödinger equations ...
SOLANGE B. CAVALCANTI +3 more
doaj +1 more source
Nonlinear Pulse-Time Conversion in Radioisotope Devices: Analysis and Application Possibilities
Приборы и методы измерений, 2021 The paper considers the operation of radioisotope measuring devices under dynamic conditions, when the Poisson pulse flux at the output of the radiation detector becomes unsteady and the nonlinearity of the calibration curve of the device, the ...
A. M. Vodovozov
doaj +1 more source
FEBS Open Bio, EarlyView.In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey +4 more
wiley +1 more source
Dose-response meta-analysis: application and practice using the R software [PDF]
Epidemiology and Health, 2019 The objective of this study was to describe the general approaches of dose-response meta-analysis (DRMA) available for the quantitative synthesis of data using the R software.
Sung Ryul Shim, Jonghoo Lee
doaj +1 more source
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
Frequency response areas in the inferior colliculus: nonlinearity and binaural interaction
Frontiers in Neural Circuits, 2013 The tuning, binaural properties, and encoding characteristics of neurons in the central nucleus of the inferior colliculus (CNIC) were investigated to shed light on nonlinearities in the responses of these neurons.
Jane J Yu, Eric Daniel Young
doaj +1 more source
Conceptual and theoretical foundations of personalised learning
Образование и наука, 2022 Introduction. The urgency of the problem related to personalised learning in future teacher training is associated with the creation of an optimal range of choices in the conditions of intensive development of the informal and non-formal educational ...
E. F. Zeer, O. V. Krezhevskikh
doaj +1 more source
Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane +10 more
wiley +1 more source
Statistical Linearization Analysis of a Hydropneumatic Suspension System With Nonlinearity
IEEE Access, 2018 Hydropneumatic suspension has the characteristics of nonlinear stiffness, nonlinear friction damping, and nonlinear hydraulic damping, and therefore, it has been widely applied to heavy vehicles.
Zuti Zhang, Shuping Cao, Chunhong Ruan
doaj +1 more source