Results 41 to 50 of about 71,375 (269)
Conceptual and theoretical foundations of personalised learning
Образование и наука, 2022 Introduction. The urgency of the problem related to personalised learning in future teacher training is associated with the creation of an optimal range of choices in the conditions of intensive development of the informal and non-formal educational ...
E. F. Zeer, O. V. Krezhevskikh
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Statistical Linearization Analysis of a Hydropneumatic Suspension System With Nonlinearity
IEEE Access, 2018 Hydropneumatic suspension has the characteristics of nonlinear stiffness, nonlinear friction damping, and nonlinear hydraulic damping, and therefore, it has been widely applied to heavy vehicles.
Zuti Zhang, Shuping Cao, Chunhong Ruan
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Entropy, 2023 Several heart rate variability (HRV) characteristics of patients with myocardial ischemia are associated with a higher mortality risk. However, the immediate effect of acute ischemia on the HRV nonlinear dynamical behavior is unknown.
Martín Calderón-Juárez +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
A Convergence Theorem for the Nonequilibrium States in the Discrete Thermostatted Kinetic Theory
Mathematics, 2019 The existence and reaching of nonequilibrium stationary states are important issues that need to be taken into account in the development of mathematical modeling frameworks for far off equilibrium complex systems.
Carlo Bianca, Marco Menale
doaj +1 more source
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
Frontiers in Psychology, 2012 This paper provides a general framework for the use of TDS in the field of psychotherapy research. Psychotherapy is inherently dynamic, namely a function of time. Consequently, the improvement of construct validity and clinical relevance of psychotherapy
Sergio eSalvatore, Wolfgang eTschacher
doaj +1 more source
A Class of Nonlinear Schrödinger Equations with Concentrated Nonlinearity
Journal of Functional Analysis, 2001 The authors of this interesting paper consider the one-dimensional nonlinear Schrödinger equation with a nonlinearity concentrated in a finite number of points. The Schrödinger equation has the form: \[ i(\partial /\partial t)\psi (t)=-\triangle \psi (t)+\sum_{j=1}^n\alpha _j(t)\delta _{y_j}\psi (t), \quad \psi (0)=\psi _0, \] where \(\delta _{y_j ...
Adami, Riccardo, Teta, Alessandro
openaire +3 more sources