Results 121 to 130 of about 607,794 (304)

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

Advanced Science, EarlyView.
Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su, Yue Zhao, Jianxiao Wu, Hao Li, Changyou Zhan, Xihui Gao   +14 more
wiley   +1 more source

A Copula-Driven CNN-LSTM Framework for Estimating Heterogeneous Treatment Effects in Multivariate Outcomes

Mathematics
Estimating heterogeneous treatment effects (HTEs) across multiple correlated outcomes poses significant challenges due to complex dependency structures and diverse data types.
Jong-Min Kim
doaj   +1 more source

Granzyme B PET Imaging Reveals Lgmn+ Macrophage‐Mediated Immune Evasion and Guides Immunotherapy in EGFR‐TKI‐Resistant NSCLC

Advanced Science, EarlyView.
Graphical illustration of 68Ga‐GZB PET/CT imaging reveals immune dynamics post‐EGFR‐TKI resistance in NSCLC; Lgmn+ macrophages‐derived Lgmn‐containing extracellular vesicles inhibit glycolysis, induce CD8+ T cell exhaustion, and targeting Lgmn restores immunotherapy sensitivity.
Dongliang Wang, Wenqin Luo, Qiufang Liu, Wenxuan Tang, Bin Zhu, Jiwei Chen, Qian Zhou, Shuang Tang, Xiaoping Xu, Shaoli Song   +9 more
wiley   +1 more source

Nonparametric Modelling of Ship Dynamics Using Puma Optimizer Algorithm-Optimized Twin Support Vector Regression

Journal of Marine Science and Engineering
Ship dynamic models serve as the foundation for designing ship controllers, trajectory planning, and obstacle avoidance. Support vector regression (SVR) is a commonly used nonparametric modelling method for ship dynamics.
Lichao Jiang, Zhi Zhang, Lingyun Lu, Xiaobing Shang, Wei Wang   +4 more
doaj   +1 more source

DETERMINISTIC NONPARAMETRIC MARKET POWER TESTS: AN EMPIRICAL INVESTIGATION [PDF]

A review of recent literature reflects the development of several deterministic nonparametric market power tests. We use Monte Carlo experiments to evaluate the veracity of four monopolistic and four monopsonistic market power tests that use the ...
Raper, Kellie Curry, Noelke, Corinna M.
core  

How Video‐Based Information Affects Farmers' Willingness to Pay for Drone Services

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Professional service for digital technology like agricultural drones lowers transaction costs and scope thresholds for smallholders. Meanwhile, perceptual adoption barriers remain underexplored. We conduct a two‐stage choice experiment with a randomized video‐based information treatment among 384 Chinese crop farmers to measure its effect on ...
Hua Zhang, Lena Kuhn, Hang Xiong, Zhanli Sun, Thomas Glauben   +4 more
wiley   +1 more source

Exploratory Graph Analysis of the Modern Racism Scale in Brazil

Avaliação Psicológica
The study aimed to gather validity evidence based on the internal structure of the Modern Racism Scale (MRS) in a racially diverse Brazilian adult sample (N=312) and to test whether the structure is invariant between White and Black (Black and mixed-race)
Nara Maria Forte Diogo Rocha, Esthela Sá Cunha, Walberto Silva dos Santos, Rodrigo da Silva Maia, Francisco Pablo Huascar Aragão Pinheiro   +4 more
doaj   +1 more source

Simple nonparametric estimators for unemployment duration analysis [PDF]

"We consider an extension of conventional univariate Kaplan-Meier type estimators for the hazard rate and the survivor function to multivariate censored data with a censored random regressor.
Wilke, Ralf A., Wichert, Laura
core  

What Really Drives Agri‐Environment‐Climate Measures' Adoption? Mandatory Requirements, Behavioral Traits, and Structural Factors in the CAP Green Architecture

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT To increase farmer adoption of green practices, the EU Common Agricultural Policy includes both mandatory (conditionality) and voluntary instruments (eco‐schemes–ECS– and more demanding, multi‐annual agri‐environment‐climate measures –AECM–). Building on the experiment of Barreiro‐Hurle et al.
L. Sanchez‐Mata, M. Rodríguez‐Entrena, M. Espinosa‐Goded, F. J. Dessart, J. Barreiro‐Hurlé   +4 more
wiley   +1 more source

Estimation of Value at Risk : Extreme Value and Robust Approaches

Operations Research and Decisions, 2010
The large portfolios of traded assets held by many financial institutions have made the measurement of market risk a necessity. In practice, VaR measures are computed for several holding periods and confidence levels.
Grażyna Trzpiot, Justyna Majewska
doaj