Results 71 to 80 of about 607,794 (304)
Advanced Science, EarlyView.In this study, we unveil a thymus‐brain endocrine axis wherein Tα1 engages HCRTR1 to inhibit RIPK3‐mediated necroptosis. This study nominates the Tal‐HCRTR1‐RIPK3 axis as a potent and clinically translatable therapeutic target for stroke and neurodegeneration.
Xinmei Kang +11 more
wiley +1 more source
A Nonparametric Examination of Capital-Skill Complementarity [PDF]
This paper uses nonparametric kernel methods to construct observation-specific elasticities of substitution for a balanced panel of 73 developed and developing countries to examine the capital-skill complementarity hypothesis.
Henderson, Daniel J.
core
Advanced Science, EarlyView.A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait +7 more
wiley +1 more source
Robustness versus Efficiency for Nonparametric Correlation Measures [PDF]
, 2008 Nonparametric correlation measures at the Kendall and Spearman correlation are widely used in the behavioral sciences. These measures are often said to be robust, in the sense of being resistant to outlying observations.
Croux, Christophe, Dehon, Catherine
core +1 more source
Advanced Science, EarlyView.Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li +8 more
wiley +1 more source
Data transformation: an underestimated tool by inappropriate use
Acta Scientiarum. Agronomy, 2018 There are researchers who do not recommend data transformation arguing it causes problems in inferences and mischaracterises data sets, which can hinder interpretation.
João Paulo Ribeiro-Oliveira +3 more
doaj +1 more source
Regularization of Nonparametric Frontier Estimators [PDF]
In production theory and efficiency analysis, we are interested in estimating the production frontier which is the locus of the maximal attainable level of an output (the production), given a set of inputs (the production factors).
Florens, Jean-Pierre +2 more
core
Advanced Science, EarlyView.This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li +14 more
wiley +1 more source
Advanced Science, EarlyView.A microbiota‐derived metabolite, indole‐3‐pyruvic acid, suppresses macrophage ferroptosis through the AHR–NF‐κB–SLC7A11 axis. This preserves CD8+ T cell function in bladder cancer. Macrophage‐targeted nanoparticles enhance indole‐3‐pyruvic acid delivery and overcome resistance to PD‐1 blockade.
Jianwen Lao +15 more
wiley +1 more source
Sensors, 2011 We consider a problem of high-resolution array radar/SAR imaging formalized in terms of a nonlinear ill-posed inverse problem of nonparametric estimation of the power spatial spectrum pattern (SSP) of the random wavefield scattered from a remotely sensed
Stewart Santos +2 more
doaj +1 more source