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How Retroviruses Escape the Nonsense-Mediated mRNA Decay
AIDS Research and Human Retroviruses, 2015Many posttranscriptional processes are known to regulate gene expression and some of them can act as an antiviral barrier. The nonsense-mediated mRNA decay (NMD) was first identified as an mRNA quality control pathway that triggers rapid decay of mRNA containing premature stop codons due to mutations.
Vincent, Mocquet +2 more
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Unique Aspects of Plant Nonsense-Mediated mRNA Decay
Trends in Plant Science, 2015Nonsense-mediated mRNA Decay (NMD) is a eukaryotic quality-control mechanism that governs the stability of both aberrant and normal transcripts. Although plant and mammalian NMD share great similarity, they differ in certain mechanistic and regulatory aspects. Whereas SMG6 (from Caenorhabditis elegans 'suppressor with morphogenetic effect on genitalia')
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A new function for nonsense-mediated mRNA-decay factors
Trends in Genetics, 2005mRNAs often contain premature-termination (nonsense) codons as a result of mutations and RNA splicing errors. These nonsense codons cause rapid decay of the mRNAs that contain them, a phenomenon called nonsense-mediated mRNA decay (NMD). This response is thought to be a quality-control mechanism that protects cells from truncated dominant-negative ...
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Nonsense-Mediated mRNA Decay in Development, Stress and Cancer
2019Nonsense-mediated mRNA decay (NMD) is a well characterized eukaryotic mRNA degradation pathway, responsible for the identification and degradation of transcripts harboring translation termination codons in premature contexts. Transcriptome-wide studies revealed that NMD is not only an mRNA surveillance pathway as initially thought, but is also a post ...
Rafael, Fernandes +4 more
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Nonsense-mediated RNA decay: an emerging modulator of malignancy
Nature Reviews Cancer, 2022Kun Tan, Miles F Wilkinson
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The Branched Nature of the Nonsense-Mediated mRNA Decay Pathway
Trends in Genetics, 2021Zhongxia Yi, Guramrit Singh
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Quality and quantity control of gene expression by nonsense-mediated mRNA decay
Nature Reviews Molecular Cell Biology, 2019Tatsuaki Kurosaki +2 more
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Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics
Nature Reviews Molecular Cell Biology, 2004Lynne E Maquat
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Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes
Nature Reviews Molecular Cell Biology, 2015Søren Lykke-Andersen +1 more
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