Results 181 to 190 of about 41,960 (230)

Effect of nonsense-mediated mRNA decay factor SMG9 deficiency on premature aging in zebrafish. [PDF]

Commun Biol
Lai S, Shiraishi H, Sebastian WA, Shimizu N, Umeda R, Ikeuchi M, Kiyota K, Takeno T, Miyazaki S, Yano S, Shimada T, Yoshimura A, Hanada R, Hanada T.   +13 more
europepmc   +1 more source

Targeting CLK2 and serine/arginine-rich splicing factors inhibits multiple myeloma through downregulating RAE1 by nonsense-mediated mRNA decay mechanism. [PDF]

Cancer Sci
Liu Y, Liao Y, Lai S, Wu X, Liang L, Zhang Y, Wei R, Chen Y.   +7 more
europepmc   +1 more source

Structure of the Nmd4-Upf1 complex supports conservation of the nonsense-mediated mRNA decay pathway between yeast and humans. [PDF]

PLoS Biol
Barbarin-Bocahu I, Ulryck N, Rigobert A, Ruiz Gutierrez N, Decourty L, Raji M, Garkhal B, Le Hir H, Saveanu C, Graille M.   +9 more
europepmc   +1 more source

Modulation of UPF1 catalytic activity upon interaction of SARS-CoV-2 Nucleocapsid protein with factors involved in nonsense mediated-mRNA decay. [PDF]

Nucleic Acids Res
Mallick M, Boehm V, Xue G, Blackstone M, Gehring NH, Chakrabarti S.   +5 more
europepmc   +1 more source

A system of reporters for comparative investigation of EJC-independent and EJC-enhanced nonsense-mediated mRNA decay. [PDF]

Nucleic Acids Res
Kolakada D, Campbell AE, Galvis LB, Li Z, Lore M, Jagannathan S.   +5 more
europepmc   +1 more source

Nonsense-mediated mRNA decay of mRNAs encoding a signal peptide occurs primarily after mRNA targeting to the endoplasmic reticulum. [PDF]

Mol Cells
Shin MK, Chang J, Park J, Lee HJ, Woo JS, Kim YK.   +5 more
europepmc   +1 more source

Readthrough Activators and Nonsense-Mediated mRNA Decay Inhibitor Molecules: Real Potential in Many Genetic Diseases Harboring Premature Termination Codons. [PDF]

Pharmaceuticals (Basel)
Benslimane N, Loret C, Chazelas P, Favreau F, Faye PA, Lejeune F, Lia AS.   +6 more
europepmc   +1 more source

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Nonsense-mediated mRNA decay: terminating erroneous gene expression

Current Opinion in Cell Biology, 2004
Nonsense-mediated mRNA decay is a surveillance pathway that reduces errors in gene expression by eliminating aberrant mRNAs that encode incomplete polypeptides. Recent experiments suggest a working model whereby premature and normal translation termination events are distinct as a consequence of the spatial relationship between the termination codon ...
Kristian E, Baker, Roy, Parker
openaire   +4 more sources

Nonsense-mediated mRNA decay

Biochemical Society Transactions, 2008
Translation and mRNA decay are coupled processes; the link is most obvious in the case of NMD (nonsense-mediated mRNA decay). NMD is a mechanism that drastically reduces the level of mRNA harbouring PTCs (premature translation termination codons). The defining event in NMD is premature translation termination and the key question is: what distinguishes
Jikai, Wen, Saverio, Brogna
openaire   +2 more sources