Results 101 to 110 of about 371,135 (330)

Inhibiting FAT1 Blocks Metabolic Bypass to Enhance Antitumor Efficacy of TCA Cycle Inhibition through Suppressing CPT1A‐Dependent Fatty Acid Oxidation

Advanced Science, EarlyView.
This study demonstrates that mutant FAT1 promotes ASCL2‐driven, CPT1A‐dependent fatty acid oxidation, leading to resistance to CPI‐613‐mediated TCA cycle inhibition in head and neck cancer. In vivo gene depletion of mutant FAT1 with LNP‐sgFAT1 suppresses tumor growth and restores CPI‐613 sensitivity, revealing a targetable metabolic bypass with ...
Fanghui Chen, Jianqiang Yang, David O. Popoola, Fan Yang, Yajie Liu, Dongsheng Wang, Zhaohui S. Qin, Zhengjia Chen, Nabil F. Saba, Zhuo G. Chen, Yamin Li, Yong Teng   +11 more
wiley   +1 more source

Comprehensive Characterization of the Immune Microenvironment Based on Nested Resampling Machine Learning Framework Identifies TRAF3 Interacting Protein 3 as a Promising Regulator to Improve the Resistance to Immunotherapy in Glioma

Advanced Science, EarlyView.
This study develops a nested resampling machine learning framework to establish the Immune Glioma Survival Signature (IGLoS), which stratifies glioma patients and predicts immunotherapy resistance. Multi‐omics analyses reveal TRAF3IP3 as a pivotal regulator of PD‐L1 expression and T‐cell exhaustion via ERK‐NFATC2 signaling.
Yanbo Yang, Fei Wang, Yulian Zhang, Run Huang, Chuanpeng Zhang, Lu Zhao, Hanhan Dang, Xinyu Tao, Yue Lu, Dengfeng Lu, Yunsheng Zhang, Kun He, Jiancong Weng, Zhouqing Chen, Zhong Wang, Yanbing Yu   +15 more
wiley   +1 more source

Training‐Free Regulation of Grasping by Intracortical Tactile Feedback Designed via S1‐M1 Communication

Advanced Science, EarlyView.
During object grasping in macaques, information flow between the primary sensory cortex (S1) and the primary motor cortex (M1) is modulated by tactile properties of the target. Intracortical micro‐stimulation in S1 reliably evokes M1 responses that resemble those naturally generated during grasping under specific tactile conditions.
Qi Zhang, Bing Liu, Zhemeng Wang, Jiayue Zhou, Xingyi Yang, Qian Zhou, Yuwei Zhao, Siwei Li, Jin Zhou, Changyong Wang   +9 more
wiley   +1 more source

Humorous nonsense and multimodality in British and American children's poetry

The European Journal of Humour Research, 2017
Nonsense and humour are two cognitive and linguistic phenomena that frequently overlap. The focus of this article falls on chosen instances of humorous nonsense poetry, targeted at English-speaking children, which contains verbal and visual modes of ...
Elzbieta Chrzanowska-Kluczewska
doaj  

Freud y Bergson. El chiste y la risa y su relación con lo social

Arbor: Ciencia, Pensamiento y Cultura, 2007
Tomando como referencias las obras de Freud, El chiste y su relación con lo inconsciente (1905), y de Bergson, La risa (1900) se estudian los mecanismos de generación de ambos y el humorismo textual como respuesta a una sociedad opresiva y neurotizante ...
Alberto Sánchez Álvarez-Insúa
doaj   +1 more source

EFTUD2 Regulates Cortical Morphogenesis via Modulation of Caspase‐3 and Aifm1 Splicing Pathways

Advanced Science, EarlyView.
EFTUD2, a spliceosomal GTPase linked to MFDM, regulates cortical development through apoptotic control. Conditional Eftud2 knockout in murine neural stem cells induces microcephaly and cortical disorganization, while pathogenic variants drive neuronal loss.
Liping Chen, Ying Li, Yan Yu, Mingze Cai, Hao Li, Minghe Huang, Guochao Yang, Jiageng Guo, Huailin Wang, Zhihong Song, Wei Shen, Huihui Jiang, Haitao Wu   +12 more
wiley   +1 more source

Humorous TV ads and the 3WD: Evidence for generalizability of humour appreciation across media?

The European Journal of Humour Research, 2017
Individuals differ in their appreciation of jokes and cartoons with respect to the structure of the humorous material (e.g., whether the jokes and cartoons are can be categorised in terms of incongruity-resolution or in terms of nonsense), as well as ...
Jennifer Hofmann, Willibald Friedrich Ruch   +1 more
doaj   +1 more source

AntiBMPNN: Structure‐Guided Graph Neural Networks for Precision Antibody Engineering

Advanced Science, EarlyView.
AntiBMPNN, a deep learning framework that integrates antibody‐specific 3D data, MPNN, frequency‐based scoring, and AlphaFold 3, achieves superior antibody sequence design. In most cases, it outperforms ProteinMPNN, AntiFold, and AbMPNN in CDR design, demonstrating higher binding affinities and sequence recovery.
Ze‐Yu Sun, Jiayi Yuan, Divya Jaiswal, Jingxuan Ge, Tianjian Liang, Jiahui Wei, Jinghong Cao, Yulong Li, Xiaojie Chu, Yan Chen, Ying Xue, Wei Li, Tingjun Hou, Zhiwei Feng   +13 more
wiley   +1 more source

The Witch on a Vespa (and the case of the Kinetic Potatoes): Nonsense strategies and translation of Kirsi Kunnas’s poem ”Mr Pii Poo”

The European Journal of Humour Research, 2017
It has been suggested that in nonsense literature the form sometimes directs the events of the story (Tigges 1988, Lecercle 1994). Translation of a poem may make this even more evident, as with "Mr Pii Poo" (1956, originally “Herra Pii Poo”), a poem by ...
Sirke Happonen
doaj   +1 more source

A Subcircuit in the Suprachiasmatic Nucleus Generates Wakefulness

Advanced Science, EarlyView.
This study identifies a sub‐circuit within the circadian pacemaker suprachiasmatic nucleus (SCN) that promotes arousal. This sub‐circuit is labeled by the clock output molecule mWAKE, which suppresses its excitability in a time‐dependent manner. mWAKE‐expressing cells in the SCN (SCNmWAKE cells) project to the subparaventricular zone (SPZ) to mediate ...
Qiang Liu, Sang Soo Lee, Jiali Xiong, Shahin Ahmadi, Benjamin J. Bell, Mehmet F. Keles, Mark N. Wu   +6 more
wiley   +1 more source