Results 31 to 40 of about 137,506 (304)
, 2015 The essay explores Lear’s contribution to the Victorian aesthetic debate, characterized by a marked resistance to the literary use of sensation (epitomised in Wilkie Collins’ fiction), and in which, according to Bourdieau and to many critics after him ...
Antinucci, Raffaella
core +1 more source
Game without game: to Gilles Deleuze’s game concept
Семиотические исследованияThe article provides a critical analysis of the "ideal game" concept by Gilles Deleuze. The problematic type of Deleuze's judgments about the game leads to the fact that the game is understood by him as a logical subject devoid of the predicate.
Yuriy A. Razinov, Dmitriy A. Kechaev
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
, 2016 There is within all theological utterances something of the ridiculous, perhaps more so in Christianity, given its proclivity for the paradoxical and the childlike.
Gabelman, Josephine
core
Microbial Cell, 2015 We have determined the nucleotide sequence of the mim3-1 mitochondrial ribosomal suppressor, acting on ochre mitochondrial mutations and one frameshift mutation in Saccharomyces cerevisiae.
Ali Gargouri +2 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
PhysicsResearchSurvivalManual nonsense [PDF]
, 2014 <p>just for the use of zenodo</p ...
OctoMiao
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular approaches fighting nonsense [PDF]
, 2021 : Nonsense mutations are the result of single nucleotide substitutions in the DNA that change a sense codon (coding for an amino acid) to a nonsense or premature termination codon (PTC) within the coding region of the mRNA [...]
Ivana Pibiri, Pibiri I.
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Molecular Cell, 2003 Abstract Nonsense-mediated decay (NMD) is a putative quality-control mechanism that degrades mRNAs containing premature termination codons (PTCs). Although many of the proteins essential for NMD have been elucidated, it is unclear how these proteins cooperate to elicit NMD.
openaire +2 more sources