Results 31 to 40 of about 27,331 (253)
Molecular Cell, 2003 Abstract Nonsense-mediated decay (NMD) is a putative quality-control mechanism that degrades mRNAs containing premature termination codons (PTCs). Although many of the proteins essential for NMD have been elucidated, it is unclear how these proteins cooperate to elicit NMD.
openaire +2 more sources
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source
Frontiers in Neurology, 2022 BackgroundHomozygous or compound heterozygous mutations in the high-temperature requirement A serine protease 1 gene (HTRA1) elicits cerebral autosomal recessive arteriopathy with subcortical infarcts and white matter lesions (CARASIL).
Weijie Chen +5 more
doaj +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
, 2010 Like the purpose for which it was built, the physical remains of Fort Nonsense eventually were erased by the elements and other factors, until very little of the original structure could be seen.
Beards, Daniel E.
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The nonsense as a hermeneutical problem in the phenomenon of new technologies [PDF]
Civilizar, 2010 This article shows how the concept of oblivion of Being (Seinsvergessenheit) developed in the first phase of Heidegger’s work can be applied to its second phase in which he discusses the phenomenon of technique.
Andrea Cortés-Boussac
doaj
Theragnosis for Duchenne Muscular Dystrophy
Frontiers in Pharmacology, 2021 Dystrophinopathies cover a spectrum of rare progressive X-linked muscle diseases, arising from DMD mutations. They are among the most common pediatric muscular dystrophies, being Duchenne muscular dystrophy (DMD) the most severe form.
Leonela Luce +12 more
doaj +1 more source
, 2012 5-Lipoxygenase (5-LO) catalyzes the two initial steps in the biosynthesis of leukotrienes (LT), a group of inflammatory lipid mediators derived from arachidonic acid.
Laura Pufahl (182448) +26 more
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Nonsense: a user's guide [PDF]
, 2022 Many philosophers suppose that sometimes we think we are saying or thinking something meaningful when in fact we’re not saying or thinking anything at all: we are producing nonsense. But what is nonsense?
Oza, Manish
core