Results 31 to 40 of about 435,524 (391)
The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy
Nature Genetics, 2019 Premature termination codons (PTCs) can result in the production of truncated proteins or the degradation of messenger RNAs by nonsense-mediated mRNA decay (NMD).
Rik G. H. Lindeboom +3 more
semanticscholar +1 more source
“E is for Ernest who choked on a peach”
The European Journal of Humour Research, 2022 In Edward Gorey’s numerous scenes of breakfasts, lunches, dinners, and afternoon teas, food and drink often feature with more or less prominence and are sometimes even found in the titles of his books, such as in The Fatal Lozenge (1960) or The Unknown ...
Nikola Novaković
doaj +1 more source
N6-methyladenosine Modulates Nonsense-mediated mRNA Decay in Human Glioblastoma.
Cancer Research, 2019 The N6-methyladenosine (m6A) modification influences various mRNA metabolic events and tumorigenesis, however, its functions in nonsense-mediated mRNA decay (NMD) and whether NMD detects induced carcinogenesis pathways remain undefined.
Fuxi Li +19 more
semanticscholar +1 more source
An engineered Tetrahymena tRNA(Gln) for in vivo incorporation of unnatural amino acids into proteins by nonsense suppression [PDF]
, 1996 A new tRNA, THG73, has been designed and evaluated as a vehicle for incorporating unnatural amino acids site-specifically into proteins expressed in vivo using the stop codon suppression technique.
Abelson, John N. +7 more
core +1 more source
UPFront and center in RNA decay: UPF1 in nonsense-mediated mRNA decay and beyond
RNA: A publication of the RNA Society, 2019 Nonsense-mediated mRNA decay (NMD), which is arguably the best-characterized translation-dependent regulatory pathway in mammals, selectively degrades mRNAs as a means of post-transcriptional gene control.
Yoon Ki Kim, L. Maquat
semanticscholar +1 more source
Nonsense correlations in neuroscience
bioRxiv, 2020 Many neurophysiological signals exhibit slow continuous trends over time. Because standard correlation analyses assume that all samples are independent, they can yield apparently significant “nonsense correlations” even for signals that are completely ...
K. Harris
semanticscholar +1 more source
Suppressing nonsense--a surprising function for 5-azacytidine. [PDF]
, 2014 In this issue of EMBO Molecular Medicine, Bhuvanagiri et al report on a chemical means to convert molecular junk into gold. They identify a chemical inhibitor of a quality control pathway that is best known for its ability to clear cells of rubbish, but ...
Shao, Ada, Wilkinson, Miles F
core +2 more sources
The Triumph of Nonsense in Management Studies
Academy of Management Learning & Education, 2019 More management scholars than ever are expressing concern about the state of our field. Complaints include the suggestion that many publications are written purely to further our careers rather tha...
D. Tourish
semanticscholar +1 more source
2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations
Nature Communications, 2020 Nonsense mutations cause about 10% of genetic disease cases, and no treatments are available. Nonsense mutations can be corrected by molecules with nonsense mutation readthrough activity. An extract of the mushroom Lepista inversa has recently shown high-
Carole Trzaska +21 more
semanticscholar +1 more source
The Metaphysical Subject and Logical Space: Solipsism and Singularity in the Tractatus
Open Philosophy, 2018 This essay presents a heterodox reading of the issue of solipsism in Wittgenstein’s Tractatus Logico-Philosophicus (TLP), out of which the whole of the TLP can be re-read.
Allen M. Curtis
doaj +1 more source