Results 21 to 30 of about 150,765 (242)

Characterization and Prognostic Value of Mutations in Exons 5 and 6 of the p53 Gene in Patients with Colorectal Cancers in Central Iran

open access: yesGut and Liver, 2013
Background/AimsWe aimed to investigate the relation-ships among various mutations of the p53 gene and their protein products, histological characteristics, and disease prognosis of primary colorectal cancer in Isfahan, central Iran.Methods : Sixty-one ...
doaj   +1 more source

Nonsense-mediated decay machinery in Plasmodium falciparum is inefficient and non-essential

open access: yes, 2023
Nonsense-mediated decay (NMD) is a conserved mRNA quality control process that eliminates transcripts bearing a premature termination codon. In addition to its role in removing erroneous transcripts, NMD is involved in post-transcriptional regulation of ...
Steven Batinovic (9481151)   +5 more
core   +1 more source

Post-transcriptional regulation of 5-lipoxygenase mRNA expression via alternative splicing and nonsense-mediated mRNA decay [PDF]

open access: yes, 2012
5-Lipoxygenase (5-LO) catalyzes the two initial steps in the biosynthesis of leukotrienes (LT), a group of inflammatory lipid mediators derived from arachidonic acid.
Laura Pufahl (182448)   +26 more
core   +2 more sources

Making (Non)Sense of the Sea, Sand and Self in The Boy in the Bush by D.H. Lawrence and M.L. Skinner

open access: yesÉtudes Lawrenciennes, 2023
In this paper, I discuss how Lewis Carroll’s Alice narratives, and in particular his so-called nonsense poem “The Walrus and the Carpenter” (from Through the Looking-Glass, 1871), can read as subtexts to the opening chapters of The Boy in the Bush by D.H.
Shirley Bricout
doaj   +1 more source

Nonsense: a user's guide [PDF]

open access: yes, 2022
Many philosophers suppose that sometimes we think we are saying or thinking something meaningful when in fact we’re not saying or thinking anything at all: we are producing nonsense. But what is nonsense?
Oza, Manish
core   +2 more sources

Acto poético <> Acto psicoanalítico: literatura, retórica y nonsense

open access: yesActa Poética, 2017
El psicoanálisis intenta captar el deseo del sujeto “al pie de la letra”: literatura y psicoanálisis comparten el hecho de que se crean nuevos mundos a partir de la palabra.
Norman Marín Calderón
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Nascent State

open access: yesPhilosophies
I suggest here ecologies of the nascent state, posing the following general questions: what is this state and what is it to live, to fabricate modes of life, in its immanence?
Filipe Ferreira
doaj   +1 more source

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