Results 11 to 20 of about 435,524 (391)

A preliminary reading of Sean Bonney’s ‘What Teargas is For’

open access: yesJournal of British and Irish Innovative Poetry, 2022
This essay supplements Sean Bonney’s note-taking and note-playing practice by discussing the role of mysticism in his later work, roughly ranging from 2011 to 2019, in order to offer a preliminary reading of the poem ‘What Teargas is For’.
Robert Kiely
doaj   +2 more sources

CFTR mRNAs with nonsense codons are degraded by the SMG6-mediated endonucleolytic decay pathway

open access: yesNature Communications, 2022
Approximately 10% of cystic fibrosis patients harbor nonsense mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene which can generate nonsense codons in the CFTR mRNA and subsequently activate the nonsense-mediated decay (NMD)
E. Sanderlin   +6 more
semanticscholar   +1 more source

Efficient suppression of endogenous CFTR nonsense mutations using anticodon-engineered transfer RNAs

open access: yesbioRxiv, 2021
Nonsense mutations or premature termination codons (PTCs) comprise ∼11% of all genetic lesions, which result in over 7,000 distinct genetic diseases. Due to their outsized impact on human health, considerable effort has been made to find therapies for ...
Wooree Ko   +4 more
semanticscholar   +1 more source

Therapeutic promise of engineered nonsense suppressor tRNAs

open access: yesWiley Interdisciplinary Reviews - RNA, 2021
Nonsense mutations change an amino acid codon to a premature termination codon (PTC) generally through a single‐nucleotide substitution. The generation of a PTC results in a defective truncated protein and often in severe forms of disease. Because of the
Joseph J. Porter   +2 more
semanticscholar   +1 more source

To NMD or Not To NMD: Nonsense-Mediated mRNA Decay in Cancer and Other Genetic Diseases.

open access: yesTrends in Genetics, 2020
The nonsense-mediated mRNA decay (NMD) pathway degrades some but not all mRNAs bearing premature termination codons (PTCs). Decades of work have elucidated the molecular mechanisms of NMD.
F. Supek   +2 more
semanticscholar   +1 more source

Evaluating Effect Size in Psychological Research: Sense and Nonsense

open access: yesAdvances in Methods and Practices in Psychological Science, 2019
Effect sizes are underappreciated and often misinterpreted—the most common mistakes being to describe them in ways that are uninformative (e.g., using arbitrary standards) or misleading (e.g., squaring effect-size rs). We propose that effect sizes can be
D. Funder, D. Ozer
semanticscholar   +1 more source

Acto poético <> Acto psicoanalítico: literatura, retórica y nonsense

open access: yesActa Poética, 2017
El psicoanálisis intenta captar el deseo del sujeto “al pie de la letra”: literatura y psicoanálisis comparten el hecho de que se crean nuevos mundos a partir de la palabra.
Norman Marín Calderón
doaj   +1 more source

Nonsense on Stilts [PDF]

open access: yes, 2006
Goverment and press have joined forces in a campaign to abandon the human rights act- and maybe membership of the ...
Petley, J
core   +1 more source

Nonsense mutations in alpha-II spectrin in three families with juvenile onset hereditary motor neuropathy [PDF]

open access: yes, 2019
Distal hereditary motor neuropathies are a rare subgroup of inherited peripheral neuropathies hallmarked by a length-dependent axonal degeneration of lower motor neurons without significant involvement of sensory neurons.
Asselbergh, B   +10 more
core   +1 more source

A role for non-B DNA forming sequences in mediating microlesions causing human inherited disease [PDF]

open access: yes, 2015
Missense/nonsense mutations and micro-deletions/micro-insertions of
Aguilera   +86 more
core   +1 more source

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