Results 61 to 70 of about 13,282 (244)
Advanced Science, EarlyView.BMSCmotif+miR874/MS system is designed as a gene delivery platform utilizing engineered bone marrow mesenchymal stem cell (BMSC)‐derived extracellular vesicles (EVs) for intercellular communication to achieve sustained delivery of miRNA‐874‐3p. Rejuvenation of chondrocytes and promotion of chondrogenesis are achieved by inhibition of the NF‐κB pathway,
Yuezhou Wu +7 more
wiley +1 more source
Advanced Science, EarlyView.This study demonstrates that mutant FAT1 promotes ASCL2‐driven, CPT1A‐dependent fatty acid oxidation, leading to resistance to CPI‐613‐mediated TCA cycle inhibition in head and neck cancer. In vivo gene depletion of mutant FAT1 with LNP‐sgFAT1 suppresses tumor growth and restores CPI‐613 sensitivity, revealing a targetable metabolic bypass with ...
Fanghui Chen +11 more
wiley +1 more source
Advanced Science, EarlyView.Obese gut‐microbiota derived lipopolysaccharides (LPS) induce bone marrow macrophage senescence and GCA secretion via activating TLR4/NF‐κB/MAPKs pathway. Clinically, obese patients are associated with higher serum GCA levels. Mice with depletion of GCA gene show resistance to skeletal deterioration caused by obesity and LPS‐induced chronic ...
Min Huang +16 more
wiley +1 more source
CeiTEA: Adaptive Hierarchy of Single Cells with Topological Entropy
Advanced Science, EarlyView.CeiTEA, a novel hierarchical clustering algorithm based on topological entropy, effectively captures complex structures underlying data. By constructing an adaptive multi‐nary partition tree, CeiTEA reveals hierarchical structures and local diversifications, outperforming existing methods in clustering accuracy and consistency and providing the ...
Bowen Tan +3 more
wiley +1 more source
Freud y Bergson. El chiste y la risa y su relación con lo social
Arbor: Ciencia, Pensamiento y Cultura, 2007 Tomando como referencias las obras de Freud, El chiste y su relación con lo inconsciente (1905), y de Bergson, La risa (1900) se estudian los mecanismos de generación de ambos y el humorismo textual como respuesta a una sociedad opresiva y neurotizante ...
Alberto Sánchez Álvarez-Insúa
doaj +1 more source
EFTUD2 Regulates Cortical Morphogenesis via Modulation of Caspase‐3 and Aifm1 Splicing Pathways
Advanced Science, EarlyView.EFTUD2, a spliceosomal GTPase linked to MFDM, regulates cortical development through apoptotic control. Conditional Eftud2 knockout in murine neural stem cells induces microcephaly and cortical disorganization, while pathogenic variants drive neuronal loss.
Liping Chen +12 more
wiley +1 more source
La pedagogía poética infantil transoceánica: cotejo de Mª Elena Walsh y Gloria Fuertes
Anuario de Investigación en Literatura Infantil y Juvenil, 2015 La presente investigación destaca la obra infantil de las poetas Gloria Fuertes y María Elena Walsh, dos autoras que han sabido conquistar al público infantil a través de sus poesías, sus cuentos, su ritmo particular y su música.
Elena Guichot Muñoz +1 more
doaj
Humorous TV ads and the 3WD: Evidence for generalizability of humour appreciation across media?
The European Journal of Humour Research, 2017 Individuals differ in their appreciation of jokes and cartoons with respect to the structure of the humorous material (e.g., whether the jokes and cartoons are can be categorised in terms of incongruity-resolution or in terms of nonsense), as well as ...
Jennifer Hofmann +1 more
doaj +1 more source
A Wearable In‐Pad Diagnostic for the Detection of Disease Biomarkers in Menstruation Blood
Advanced Science, EarlyView.MenstruAI integrates a paper‐based biosensor into sanitary pads to detect biomarkers in menstrual blood, enabling accessible, lab‐free diagnostics health. The platform supports early disease detection, especially in underserved communities, while challenging menstrual stigma and opening pathways for scalable, inclusive, and sustainable population ...
Lucas Dosnon +3 more
wiley +1 more source
The European Journal of Humour Research, 2017 It has been suggested that in nonsense literature the form sometimes directs the events of the story (Tigges 1988, Lecercle 1994). Translation of a poem may make this even more evident, as with "Mr Pii Poo" (1956, originally “Herra Pii Poo”), a poem by ...
Sirke Happonen
doaj +1 more source