Results 71 to 80 of about 13,282 (244)

Engineering Adenine Deaminase TadA for Precise and PAM‐Flexible Point Mutagenesis and Gradient‐Tuning Endogenous Protein Design

Advanced Science, EarlyView.
Base editing enables precise nucleotide substitutions but limited by bystander editing. This study engineers plant base editors by fusing optimized TadA variants with PAM‐flexible SpRY nickase, enabling A‐to‐G, C‐to‐T, and dual‐base conversions in a highly condensed window (≤3 nucleotides). Additionally, TadDBE (TadA Dual‐Base Editor)‐mediated directed
Kangli Sun, Si Cheng, Nan Chai, Jianing Mi, Ruixiang Zhang, Qian Qian, Zhiye Zheng, Ke Chen, Dongchang Zeng, Xin Peng, Mengyuan Shen, Degui Zhou, Qinlong Zhu, Qi Liu, Jiantao Tan   +14 more
wiley   +1 more source

Magnetically Controllable and Degradable Milliscale Swimmers as Intraocular Drug Implants

Advanced Science, EarlyView.
Magnetically controllable degradable milliscale swimmers (MDMS) offer a promising alternative to commercial intraocular drug implants, reducing complications like implant dislocation and uncontrolled drug release. MDMS achieve high velocities in ocular environments, enable real‐time imaging, and deliver drugs effectively without disrupting retinal ...
Erdost Yildiz, Ugur Bozuyuk, Eray Yildiz, Fan Wang, Mertcan Han, Alp Can Karacakol, Devin Sheehan, Yan Yu, Metin Sitti   +8 more
wiley   +1 more source

Characterization and Prognostic Value of Mutations in Exons 5 and 6 of the p53 Gene in Patients with Colorectal Cancers in Central Iran

Gut and Liver, 2013
Background/AimsWe aimed to investigate the relation-ships among various mutations of the p53 gene and their protein products, histological characteristics, and disease prognosis of primary colorectal cancer in Isfahan, central Iran.Methods : Sixty-one ...
doaj   +1 more source

Czym są tak zwane tezy Traktatu? Drabina Wittgensteina

Analiza i Egzystencja, 2017
The main objective of my article is the presentation and critical analysis of two possible interpretations of the Tractatus Logico-Philosophicus. I juxtapose the so-called resolute reading with the metaphysical reading.
Jan Wawrzyniak
doaj   +1 more source

Zoological Nonsense [PDF]

, 1875

openalex   +1 more source

Using Dopants as Agents to Probe Key Electronic Properties of Organic Semiconductors

Advanced Electronic Materials, EarlyView.
Dopants are typically used in organic electronics to enhance conductivity, but here their potential is demonstrated as probes for fundamental material properties. By integrating experimental data and multiscale simulations, it is shown how dopant ionization and conductivity measurements enable accurate extraction of ionization potential and Coulomb ...
Artem Fediai, Franz Symalla, Tobias Neumann, Wolfgang Wenzel   +3 more
wiley   +1 more source

The Nascent State

Philosophies
I suggest here ecologies of the nascent state, posing the following general questions: what is this state and what is it to live, to fabricate modes of life, in its immanence?
Filipe Ferreira
doaj   +1 more source

Uncle Joe's Nonsense: for Young and Old Children [PDF]

, 1934
J. R.
openalex   +1 more source

U.S. Consumer Preferences for Cage‐Free Eggs and Hen Housing Policies

Agribusiness, EarlyView.
ABSTRACT Farm animal welfare (FAW) continues to be a divisive issue in the egg industry. In the United States, 10 states and most major retailers have implemented policies or voluntary pledges to transition to 100% cage‐free egg sales. We use best‐worst scaling and discrete choice experiments to evaluate U.S.
Vincenzina Caputo, Aaron J. Staples, Jayson L. Lusk, Glynn T. Tonsor   +3 more
wiley   +1 more source

Humorous nonsense and multimodality in British and American children's poetry

The European Journal of Humour Research, 2017
Nonsense and humour are two cognitive and linguistic phenomena that frequently overlap. The focus of this article falls on chosen instances of humorous nonsense poetry, targeted at English-speaking children, which contains verbal and visual modes of ...
Elzbieta Chrzanowska-Kluczewska
doaj