Results 141 to 150 of about 62,957 (275)
Genetic analysis of primary lung interdigitating dendritic cell sarcomas
The Journal of Pathology, EarlyView.Abstract Interdigitating dendritic cell sarcomas (IDCSs) are rare tumors that commonly arise in the hematopoietic system and rarely outside. The genetic drivers of IDCS carcinogenesis are unknown; therefore, therapeutic options are limited. We investigated somatic gene mutations and copy‐number alterations (CNAs) in nine IDCSs arising in the lung by ...
Mikhail S Ermakov +6 more
wiley +1 more source
Ewing sarcoma in a child with neurofibromatosis type 1. [PDF]
, 2019 We report here on a case of Ewing sarcoma (ES) occurring in a child with neurofibromatosis type 1. The sarcoma had an EWSR1-ERG translocation as well as loss of the remaining wild-type allele of NF1. Loss of the NF1 wild-type allele in the tumor suggests
Bastian, Boris C +6 more
core
PLANTS, PEOPLE, PLANET, EarlyView.Utility‐scale solar energy (USSE) development generates novel questions regarding coupling clean energy production with terrestrial ecosystem services (e.g., forage production, pollinator support). We found that a USSE array sited in a fallowed cropland maintained a reseeded native plant community even a decade post‐restoration and that the array ...
Caitlin Robertson +2 more
wiley +1 more source
Regional Sustainability Assessment Under Risk and Uncertainty: A Water–Energy–Food Based Framework
Sustainable Development, EarlyView.ABSTRACT Regional sustainability assessment requires integrated structures that can examine the interactions between Water–Energy–Food (WEF) systems, socio‐economic risk conditions, and performance outcomes under uncertainty. This study proposes a multidimensional framework that combines a suitability index, composite sustainability indicators ...
Murat Oturakci
wiley +1 more source
System as a Unifying Process: An Onto‐Epistemic Notion of System
Systems Research and Behavioral Science, EarlyView.ABSTRACT This article proposes an onto‐epistemic notion of system as a relational process of unifying a multiplicity of actuals and abstractions into an actual unity, thereby encompassing concreteness and abstraction onto the same plane. This notion rejects the opposition between constructivism and realism within systems studies, the excessive focus on
Felipe Rodrigues Oliveira e Silva +1 more
wiley +1 more source
Symbolic Interaction, EarlyView.This study of first‐year primary school draws on Goffman's concept of “collective behavior” to examine how order is established and disrupted through the mutual adjustment of all participants' actions. We employed a multi‐method longitudinal design, using semi‐standardized observations and qualitative interviews with teachers and children at three ...
Doris Bühler‐Niederberger +2 more
wiley +1 more source
Unnatural Amino Acid‐Based Ionic Liquid Enables Oral Treatment of Nonsense Mutation Disease in Mice
Advanced ScienceThis investigation addresses the challenge of suboptimal unnatural amino acid (UAA) utilization in the site‐specific suppression of nonsense mutations through genetic code expansion, which is crucial for protein restoration and precise property tailoring.
Yujie Shi +4 more
doaj +1 more source
Molecular Insights into Determinants of Translational Readthrough and Implications for Nonsense Suppression Approaches. [PDF]
Int J Mol Sci, 2020 Lombardi S +3 more
europepmc +1 more source
VIEW, EarlyView.We created a coculture system using patient‐derived organoids (PDOs) and tumor‐infiltrating lymphocytes (TILs) that mimics important interactions between PDOs and TILs in the presence of various ICIs. Our findings reveal that CD62L+ T cells, activated by CD44+ cancer stem cells (CSCs), facilitate tumor regression in samples sensitive to ICIs, which is ...
Jie Chen +9 more
wiley +1 more source
Nonsense Suppression Therapy: New Hypothesis for the Treatment of Inherited Bone Marrow Failure Syndromes. [PDF]
Int J Mol Sci, 2020 Bezzerri V +5 more
europepmc +1 more source