Results 151 to 160 of about 20,553 (236)

Splicing Factor Mutations in Clonal Hematopoiesis and Progression to Myeloid Neoplasms

Cancer Science, EarlyView.
Splicing factor (SF)‐mutant CH is characterized by relatively late emergence and accelerated clonal expansion in older individuals. This review summarizes its clonal dynamics, disease‐associated consequences of SF mutations in myeloid neoplasms, and candidate mechanisms that may contribute to age‐dependent selection.
Yang Lyu, Yutong Zhang, Ayana Kon
wiley   +1 more source

Elucidating PI3K/AKT/PTEN Pathway Alterations at Single‐Cell Level in CTCs From HR+/HER2− Metastatic Breast Cancer

Cancer Science, EarlyView.
Single CTC analysis revealed extensive inter‐ and intra‐patient heterogeneity of PI3K/AKT/PTEN pathway alterations in HR+/HER2− metastatic breast cancer, capturing both SNVs and CNAs, including PTEN loss‐of‐function events. Longitudinal CTC profiling also uncovered dynamic clonal evolution, highlighting its potential to complement tissue and ctDNA ...
Tania Rossi, Michela Palleschi, Caterina Gianni, Filippo Merloni, Alessandra Virga, Sara Bandini, Davide Angeli, Michela Tebaldi, Roberta Maltoni, Paola Ulivi, Antonino Musolino   +10 more
wiley   +1 more source

Anticodon-engineered tRNAs restore full-length MeCP2 expression and function in Rett syndrome nonsense mutations. [PDF]

Front Neurol
Fara E, Pezzini S, Arpaia G, Frasca A, Porter JJ, Lueck JD, Landsberger N.   +6 more
europepmc   +1 more source

PABPC1 in Cancer: From a Translational Housekeeper to a Stress‐Responsive Regulatory Hub

Cancer Science, EarlyView.
PABPC1 shifts from a translational housekeeper to a stress‐responsive oncogenic hub via phase separation, PTMs, and non‐coding RNA crosstalk, selectively driving oncogene translation and therapy resistance in cancer. ABSTRACT PABPC1, long recognized as a constitutive translational housekeeper, has emerged as a stress‐responsive translational ...
Cuiwei Zhang, Ye Zhu, Wenbo Long
wiley   +1 more source

PTC124 promotes mutation site-dependent readthrough of STK11 nonsense mutations and restores tumor suppressor function. [PDF]

BBA Adv
Hung CH, Wang HH, Cheng YT, Chen JY, Lin KY, Chen ST, Pan TY, Lin HJ, Chen CC, Cai BH.   +9 more
europepmc   +1 more source

Circles of Confidence for Multi‐Label Geometry Completion

Computer Graphics Forum, EarlyView.
Abstract Inside–outside classification is widely used for geometry processing tasks such as surface reconstruction, geometry completion, and calculating signed distance fields. We introduce a new integral formulation of this problem, which assigns confidence scores that points are inside or outside, given incomplete boundary geometry.
Z. Wei, C. Hafner, A. Kalinov, P. Heiss‐Synak, C. Wojtan   +4 more
wiley   +1 more source

Functional phosphoproteomic analysis of SMG1 in nonsense-mediated mRNA decay and DNA damage repair in cancer. [PDF]

Front Syst Biol
Pai AKA, Dcunha L, Gopalakrishnan AP, Ummar S, Rajeev AC, Raju R.   +5 more
europepmc   +1 more source

Magical Realist Hauntings in Children's Everyday Encounters With Death, or, How to Believe in Impossible Things

Children &Society, EarlyView.
ABSTRACT Modern deaths have become reiterations. That is, despite exhibiting a seemingly high‐level of diversity in death's representations in everyday lives, death suffers from a particular onto‐epistemological poverty that prevents it from being imagined otherwise.
Zhaoxi Zheng, Rebecca E. Olson, Sally Staton   +2 more
wiley   +1 more source

A methods review on use of nonsense suppression to study 3' end formation and other aspects of tRNA biogenesis. [PDF]

Gene, 2015
Rijal K, Maraia RJ, Arimbasseri AG.
europepmc   +1 more source

p21 Knockdown as a Therapeutic Strategy for Focal Cartilage Injury Repair. [PDF]

FASEB J
Larijani L, Ahadzadeh Ardebili A, Ortiz Vales N, Stürmer AT, Krawetz RJ.   +4 more
europepmc   +1 more source