Results 111 to 120 of about 161,622 (300)
Arthritis &Rheumatology, EarlyView.Objective Systemic lupus erythematosus (SLE) shows clinical and molecular heterogeneity, and cardiovascular (CV) complications and lupus nephritis (LN) remain leading causes of morbidity and mortality. This study investigated whether omic profiling can reveal molecular endotypes linked to these outcomes.
Tomás Cerdó +84 more
wiley +1 more source
Journal of International Medical ResearchFabry disease is a rare X-linked lysosomal storage disorder caused by a defect in glycosphingolipid metabolism, which leads to the accumulation of globotriaosylceramide (Gb3) in various cell types.
Guan-Qiang Tian +5 more
doaj +1 more source
Arthritis &Rheumatology, EarlyView.Objective To examine the association between radiographic structural damage and physical function (PF) in psoriatic arthritis (PsA). Methods Data were analyzed from a large longitudinal PsA cohort. PF was measured using the Health Assessment Questionnaire (HAQ, 0–3) and Short Form‐36 PF subscale (SF‐36, 0–100); radiographic joint damage was measured ...
Pankti Mehta +8 more
wiley +1 more source
Gender-specific changes in energy metabolism and protein degradation as major pathways affected in livers of mice treated with ibuprofen. [PDF]
, 2020 Ibuprofen, an inhibitor of prostanoid biosynthesis, is a common pharmacological agent used for the management of pain, inflammation and fever. However, the chronic use of ibuprofen at high doses is associated with increased risk for cardiovascular, renal,
Gomes, Aldrin V +5 more
core
Arthritis &Rheumatology, EarlyView.Objective Identification of osteoarthritis (OA)–specific synovial inflammatory pathways and their temporal relevance is critical for therapeutic targeting. We compared mononuclear inflammatory/immune cell responses following joint injury that does or does not lead to OA to define bona fide OA‐associated cellular events.
Babak Moradi +10 more
wiley +1 more source
A case of chronic recurrent multifocal osteomyelitis associated with Crohn's disease [PDF]
, 2015 Chronic recurrent multifocal osteomyelitis (CRMO) is an auto-inflammatory bone disease of unknown etiology, most commonly affecting the metaphysis of long bones, especially the tibia, femur and clavicle. The clinical spectrum varies from self-limited uni-
De Baets, Frans +5 more
core
Arthroscopy Techniques, EarlyView.Abstract Meralgia paresthetica (MP) is a neuropathy caused by injury or compression of the lateral femoral cutaneous nerve (LFCN), presenting as numbness, tingling, or burning pain in the lateral thigh. While surgical decompression has traditionally been a common surgical treatment for MP, recently, fully transecting the LFCN is increasingly becoming ...
Joshua T. Finerty +3 more
wiley +1 more source
Celecoxib in arthritis: relative risk management profile and implications for patients
Therapeutics and Clinical Risk Management, 2009 Gayle McKellar1, Gurkirpal Singh21Centre for Rheumatic Diseases, Glasgow Royal Infirmary, Glasgow, UK; 2Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Palo Alto, CA, USAAbstract: Celecoxib is a selective cyclo ...
Gayle McKellar, Gurkirpal Singh
doaj
Non-steroidal anti-inflammatory drug-induced enteropathy
Intestinal Research, 2017 Non-steroidal anti-inflammatory drugs (NSAIDs) are well known to be associated with serious upper gastrointestinal complications, such as peptic ulcer, bleeding, perforation, and obstruction. Recently, attention has been mainly focused on the small bowel
Sung Jae Shin +4 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims In medical education, the ability of large language models (LLMs) to match human performance raises questions about their potential as educational tools. This study evaluates LLMs' performance on Clinical Pharmacology and Therapeutics (CPT) exams, comparing their results to medical students and exploring their ability to identify poorly formulated
Alexandre O. Gérard +11 more
wiley +1 more source