Results 121 to 130 of about 161,622 (300)

Revisiting the Ethics of Urate‐Lowering Therapy Clinical Trials for Gout Management

Arthritis &Rheumatology, EarlyView.
Lisa K. Stamp, Dien Ho, Nicola Dalbeth
wiley   +1 more source

The interplay between molecular architecture, pharmacology, and suspected adverse drug reactions associated with nonsteroidal androgen antagonists in the United Kingdom

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to correlate potential links between the suspected adverse drug reaction (ADR) profile of licensed nonsteroidal androgen receptor antagonists (NSARA) with their unique chemical properties and known off‐target polypharmacology. Methods Physicochemical and polypharmacology data were curated from the Electronic Medicines Compendium ...
Simrit Dhillon, Albert A. Antolin, Alan M. Jones   +2 more
wiley   +1 more source

Cardiorenal Outcomes of Dapagliflozin vs. Empagliflozin in Advanced Chronic Kidney Disease and Diabetes

Clinical Pharmacology &Therapeutics, EarlyView.
Target trial emulation of a multi‐institutional electronic health record network showed comparable cardiorenal effectiveness and safety of dapagliflozin versus empagliflozin in adults with type 2 diabetes and advanced‐stage chronic kidney disease.
Shih‐Hsuan Lin, Jia‐Jin Chen, Ching‐Chung Hsiao, Yu‐Wei Fang, Meng‐Ting Chen, Ming‐Hsien Tsai, Huang‐Yu Yang   +6 more
wiley   +1 more source

Efficacy and safety of nonsteroidal mineralocorticoid receptor antagonists for renal and cardiovascular outcomes in patients with chronic kidney disease: a meta-analysis of randomized clinical trials

Frontiers in Pharmacology
Objective: To systematically review the efficacy and safety of nonsteroidal mineralocorticoid receptor antagonists (MRAs) in chronic kidney disease (CKD).Methods: We systematically searched six databases to identify randomized controlled trials (RCTs ...
Qianlan Chen, Guocui Wei, Yanping Wang, Xiuxia Li, Qian Zhao, Ling Zhu, Qing Xiao, Xuan Xiong   +7 more
doaj   +1 more source

1,1‐Disubstituted Vinylbromides: Versatile Building Blocks for the Synthesis of Nitrogen‐Containing Heterocycles

European Journal of Organic Chemistry, EarlyView.
1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer, Jun Fang, Chonghuo Liu, Guillaume Lefèvre, Gérard Guillamot, Phannarath Phansavath, Virginie Ratovelomanana‐Vidal   +6 more
wiley   +1 more source

Remarkable Formation of Indene Derivatives Upon Friedel–Crafts Acylation Reactions

European Journal of Organic Chemistry, EarlyView.
This shows indene derivatives. Under the reaction conditions of a Friedel–Crafts acylation, alkyl benzenes underwent an unprecedented cyclopentannulation furnishing indene derivatives. Alkylbenzene derivatives react with two equivalents of pivaloyl chloride (PivCl) in the presence of aluminum trichloride under formation of indene derivatives with up to
Leah Bantel, Neels Kruse, Marc Schmidtmann, Jens Christoffers   +3 more
wiley   +1 more source

Heterocyclic inflammation inhibitors

Open Chemistry, 2004
Sondhi Sham, Rajvanshi Shefali, Singh Nirupma, Jain Shubhi, Lahoti Anand   +4 more
doaj   +1 more source

Case report : successful conservative treatment of a soccer player with multiple-level spondylolysis [PDF]

, 2020
Dunn, Iwamato, Klein, Liu, Nayeemuddin, Park, Selhorst, Sys, Wong   +8 more
core   +2 more sources

Comparison of opioid prescribing by dentists in the United States and England [PDF]

, 2019
Importance: The United States consumes most of the opioids worldwide despite representing a small portion of the world\u27s population. Dentists are one of the most frequent US prescribers of opioids despite data suggesting that nonopioid analgesics are ...
Calip, Gregory S, Durkin, Michael J, Gellad, Walid F, Kim, Hajwa, Lockhart, Peter B, Rowan, Susan A, Suda, Katie J, Thornhill, Martin H   +7 more
core   +1 more source

Things We Do for No Reason™: Prescribing gabapentinoids for pain

Journal of Hospital Medicine, EarlyView.
Abstract Gabapentin and pregabalin are among the most frequently prescribed medications in the United States, with gabapentin in the top 10 and pregabalin in the top 100. Despite FDA approval for only select neuropathic conditions, most use is for off‐label pain indications.
Niti G. Patel, David Goese, Steven M. Belknap, Charles L. Madeira, Jeffrey H. Barsuk   +4 more
wiley   +1 more source