Results 51 to 60 of about 160,452 (346)

Safety Evaluation of Repeated Application of Polymeric Microarray Patches in Miniature Pigs

Advanced Healthcare Materials, EarlyView.
This study demonstrates the safety of repeated application of three types of microarray patches (MAPs), hydrogelforming, dissolving, and implantable, over four weeks in miniature pigs. No adverse skin or systemic effects were observed, supporting the clinical potential of MAPs as safe and effective drug delivery platforms.
Qonita Kurnia Anjani, Aaron R. J. Hutton, Peter E. McKenna, Eneko Larrañeta, Ryan F. Donnelly   +4 more
wiley   +1 more source

NONSTEROID INFLAMMATORY MEDICINES IN PREGNANT WOMEN: THE RISKS OF ADVERSE EVENTS

Педиатрическая фармакология, 2011
The nonsteroidal anti-inflammatory agents are group of medicines, which are used widely in a clinical practice. Pregnant women use these drugs quite often on prescription and in self-treatment.
A.A. Ivanova, A.S. Kolbin
doaj   +2 more sources

Chronic pain syndrome: Pathogenesis, clinical presentation, treatment

Klinicist, 2014
The paper considers main ideas on the prevalence, course, and therapy of chronic pain syndrome. It describes its manifestations, different course variants, and approaches to treating the diseases accompanied by chronic pain.
A. Yu. Suvorov
doaj   +3 more sources

Effects of periarticular injection on analgesic effects and NSAID use in total knee arthroplasty and total hip arthroplasty

Clinics
OBJECTIVES: This study examined periarticular multimodal drug injection and the use of nonsteroidal anti-inflammatory drugs for an early analgesic effect after total knee arthroplasty and total hip arthroplasty. Patient satisfaction and benefits from the
Wen-rui Ban, Ery-ang Zhang, Lei-feng Lv, Xiao-qian Dang, Chen Zhang   +4 more
doaj   +1 more source

Immunosuppressive Cytokine‐Tethered Hydrogel for Treating Rheumatoid Arthritis

Advanced Healthcare Materials, EarlyView.
An injectable hydrogel is developed by chemically tethering IL‐4, an immunosuppressive cytokine, to a hyaluronic acid‐based backbone. The hydrogel reduces joint friction and exerts immunomodulatory effects. In a rheumatoid arthritis (RA) mouse model, it reduced inflammation, preserved cartilage, and promoted anti‐inflammatory immune responses.
Woojin Back, Moonkyoung Jeong, Huyen‐Thao Le, Ji‐Ho Park   +3 more
wiley   +1 more source

The new Era of non-Steroidal Mineralocorticoid Antagonists in Treating Heart Failure in Diabetic Kidney Disease Patients.

Albanian Journal of Trauma and Emergency Surgery, 2022
Inappropriate activation of the mineralocorticoid receptor (MR) plays a significant role in developing hypertension, the development of cardiac pathological changes, and chronic kidney disease (CKD), where death related to cardiovascular (CV) causes is ...
Eqerem Hasani, Merita Rroji, Myftar Barbullushi   +2 more
doaj   +1 more source

Dual Photoredox/Cu‐Catalysis Enables Diastereoselective Synthesis of 3‐β‐Ethynyltropanes via Decarboxylative Alkynylation

Advanced Synthesis &Catalysis, EarlyView.
A copper‐catalyzed decarboxylative alkynylation of tropanes is developed. This approach works under mild conditions and selectively produces a range of 3‐β‐alkynylated tropanes. Moreover, it provides a versatile and convergent platform for further functionalization of the triple bond.
Mayssa Zayene, Franck Le Bideau, Pascal Retailleau, Hichem Ben Jannet, Vincent Gandon, Anis Romdhane, Samir Messaoudi   +6 more
wiley   +1 more source

Analysis of analgesic, antipyretic, and nonsteroidal anti-inflammatory drug use in pediatric prescriptions

Jornal de Pediatria, 2016
OBJECTIVE: Data on clinical practice in pediatrics on the use of analgesic, antipyretic, and nonsteroidal anti-inflammatory drugs considering the best available evidence and regulatory-agency approved use are uncertain. This study aimed to determine the
Tânia R. Ferreira, Luciane C. Lopes
doaj   +1 more source

Utilization of nonsteroidal antiinflammatory drugs [PDF]

Arthritis & Rheumatism, 1985
AbstractInformation derived from pharmaceutical marketing databases on the use of 12 nonsteroidal antiinflammatory drugs in 1983 is presented. Estimates of population exposure, regularity of treatment, average daily dose, age and sex distributions of users, concomitant use of other drugs, associated diagnoses, and trends in use are provided ...
Mary B. Forbes, Dianne L. Kennedy, Carlene Baum   +2 more
openaire   +3 more sources

Mechanical Load‐Induced Upregulation of Talin2 through Non‐Canonical Deubiquitination of OTUB1 Drives Facet Joint Osteoarthritis Pathogenesis

Advanced Science, EarlyView.
Facet joint osteoarthritis (FJOA), prevalent in the elderly, involves Talin2 upregulation promoting ECM degradation while suppressing synthesis. Mechanical load stabilizes Talin2 via OTUB1‐mediated non‐canonical deubiquitination, driving CCL2 expression that recruits immune cells, exacerbating inflammatory joint degeneration.
Yizhen Huang, Heng Sun, Haojie Chen, Xiangpeng Wang, Junduo Zhao, Yang Jiao, Hongyi Zhou, Haoyu Cai, Jiafeng Dai, Xuan Huang, Weiyun Chen, Jianxiong Shen   +11 more
wiley   +1 more source