Results 11 to 20 of about 270,619 (156)

Linking the Amyloid, Tau, and Mitochondrial Hypotheses of Alzheimer’s Disease and Identifying Promising Drug Targets [PDF]

Biomolecules, 2022
Damage or loss of brain cells and impaired neurochemistry, neurogenesis, and synaptic and nonsynaptic plasticity of the brain lead to dementia in neurodegenerative diseases, such as Alzheimer’s disease (AD).
Zdeněk Fišar
doaj   +3 more sources

Faculty Opinions recommendation of Nonsynaptic NMDA receptors mediate activity-dependent plasticity of gap junctional coupling in the AII amacrine cell network.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2018
Alapakkam P. Sampath
semanticscholar   +4 more sources

Diverse impact of acute and long-term extracellular proteolytic activity on plasticity of neuronal excitability

Frontiers in Cellular Neuroscience, 2015
Learning and memory require alteration in number and strength of existing synaptic connections. Extracellular proteolysis within the synapses has been shown to play a pivotal role in synaptic plasticity by determining synapse structure, function, and ...
Tomasz eWójtowicz, Patrycja eBrzdak, Jerzy W Mozrzymas, Jerzy W Mozrzymas   +3 more
doaj   +2 more sources

Rapid Ultrastructural Changes in the PSD and Surrounding Membrane after Induction of Structural LTP in Single Dendritic Spines. [PDF]

J Neurosci, 2021
The structural plasticity of dendritic spines is considered to be an important basis of synaptic plasticity, learning, and memory. Here, we induced input-specific structural LTP (sLTP) in single dendritic spines in organotypic hippocampal slices from ...
Sun Y, Smirnov M, Kamasawa N, Yasuda R.
europepmc   +2 more sources

Intrinsic adaptation in autonomous recurrent neural networks [PDF]

Neural Computation, 2011
A massively recurrent neural network responds on one side to input stimuli and is autonomously active, on the other side, in the absence of sensory inputs.
Ashby W., Camazine S., Claudius Gros, Dimitrije Marković, Spall J. C.   +4 more
core   +2 more sources

WONOEP XVII appraisal: Targeting network excitability beyond the synapse -Neurotransmitter, ionic, and electro -diffusions. [PDF]

Epilepsia
Abstract Epilepsy affects approximately 1% of the population worldwide, and although medications are effective in the majority of cases, seizures persist in approximately 30% of patients. Despite the effort to develop new antiseizure drugs, the rate of pharmacoresistance in patients has not diminished over the past 3 decades. There is thus a real unmet
Magloire V, de Curtis M, Noebels J, Huberfeld G, Suffczynski P, Gnatkovsky V, Tyurikova O, Durand D, Henshall DC, McCafferty C.   +9 more
europepmc   +2 more sources

Optogenetic stimulation of the median preoptic nucleus: Effects on hypothalamic paraventricular nucleus magnocellular neurons after chronic intermittent hypoxia exposure. [PDF]

J Neuroendocrinol
Abstract Median preoptic nucleus (MnPO) neurons projecting to the hypothalamic paraventricular nucleus (PVN) are linked to hypertension induced by chronic intermittent hypoxia (CIH), a model of obstructive sleep apnea. The modulation of MnPO‐driven synaptic activity in PVN magnocellular neurons (MNCs) by CIH remains unexamined.
Paundralingga OT, Jia S, Farmer GE, Toney GM, Cunningham JT.   +4 more
europepmc   +2 more sources

Boosting Psychotherapy With Noninvasive Brain Stimulation: The Whys and Wherefores of Modulating Neural Plasticity to Promote Therapeutic Change. [PDF]

Neural Plast
The phenomenon of neural plasticity pertains to the intrinsic capacity of neurons to undergo structural and functional reconfiguration through learning and experiential interaction with the environment. These changes could manifest themselves not only as a consequence of various life experiences but also following therapeutic interventions, including ...
Saccenti D, Lauro LJR, Crespi SA, Moro AS, Vergallito A, Grgič RG, Pretti N, Lamanna J, Ferro M.   +8 more
europepmc   +2 more sources

Synaptic and Non-Synaptic Functions of PTPRD: A Receptor Tyrosine Phosphatase at the Crossroads of Neural Circuitry and Metabolism. [PDF]

J Neurochem
PTPRD (receptor‐type protein tyrosine phosphatase delta) translates extracellular adhesion “codes” into intracellular phosphotyrosine signaling that shapes brain circuits. Alternative inclusion of micro‐exons meA and meB sculpts PTPRD's Ig domain, dictating trans‐synaptic binding to partners such as IL1RAPL1 or IL1RAP and thereby tuning synapse ...
Kim S, Shin JJ, Kang M, Yi Y, Kim E.
europepmc   +2 more sources

A DARPin-based molecular toolset to probe gephyrin and inhibitory synapse biology

eLife, 2022
Neuroscience currently requires the use of antibodies to study synaptic proteins, where antibody binding is used as a correlate to define the presence, plasticity, and regulation of synapses. Gephyrin is an inhibitory synaptic scaffolding protein used to
Benjamin FN Campbell, Antje Dittmann, Birgit Dreier, Andreas Plückthun, Shiva K Tyagarajan   +4 more
doaj   +1 more source