Results 31 to 40 of about 265,561 (113)

The Key Genes Underlying Pathophysiology Association between Plaque Instability and Progression of Myocardial Infarction

Disease Markers, Volume 2021, Issue 1, 2021., 2021
Young patients with type 2 diabetes and myocardial infarction (MI) have higher long‐term all‐cause and cardiovascular mortality. In addition, the observed increased, mildly abnormal baseline lipid levels, but not lipid variability, are associated with an increased risk of atherosclerotic cardiovascular disease events, particularly MI.
Yue Zheng, Yijie Gong, Yuheng Lang, Zhenchang Qi, Xiaomin Hu, Tong Li, Serena Del Turco   +6 more
wiley   +1 more source

Synergistic excitability plasticity in cerebellar functioning

The FEBS Journal, 2020
The cerebellum, a universal processor for sensory acquisition and internal models, and its association with synaptic and nonsynaptic plasticity have been envisioned as the biological correlates of learning, perception, and even thought.
G. Ohtsuki, Maria Shishikura, Akitoshi Ozaki   +2 more
semanticscholar   +1 more source

Neuroinflammation: An Integrating Overview of Reactive‐Neuroimmune Cell Interactions in Health and Disease

Mediators of Inflammation, Volume 2021, Issue 1, 2021., 2021
The concept of central nervous system (CNS) inflammation has evolved over the last decades. Neuroinflammation is the response of reactive CNS components to altered homeostasis, regardless of the cause to be endogenous or exogenous. Neurological diseases, whether traumatic, neoplastic, ischemic, metabolic, toxic, infectious, autoimmune, developmental ...
Rodolfo Kölliker-Frers, Lucas Udovin, Matilde Otero-Losada, Tamara Kobiec, María Inés Herrera, Jorge Palacios, Gabriela Razzitte, Francisco Capani, Mirella Giovarelli   +8 more
wiley   +1 more source

Nonsynaptic junctions on myelinating glia promote preferential myelination of electrically active axons

Nature Communications, 2015
The myelin sheath on vertebrate axons is critical for neural impulse transmission, but whether electrically active axons are preferentially myelinated by glial cells, and if so, whether axo-glial synapses are involved, are long-standing questions of ...
H. Wake, F. Ortiz, D. H. Woo, Philip R. Lee, M. C. Angulo, R. Fields   +5 more
semanticscholar   +1 more source

Neurovascular coupling in the developing neonatal brain at rest

Human Brain Mapping, Volume 41, Issue 2, Page 503-519, February 1, 2020., 2020
Abstract The neonatal brain is an extremely dynamic organization undergoing essential development in terms of connectivity and function. Several functional imaging investigations of the developing brain have found neurovascular coupling (NVC) patterns that contrast with those observed in adults.
Mina Nourhashemi, Mahdi Mahmoudzadeh, Sabrina Goudjil, Guy Kongolo, Fabrice Wallois   +4 more
wiley   +1 more source

Autophagy and Redox Homeostasis in Parkinson’s: A Crucial Balancing Act

Oxidative Medicine and Cellular Longevity, Volume 2020, Issue 1, 2020., 2020
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated primarily from endogenous biochemical reactions in mitochondria, endoplasmic reticulum (ER), and peroxisomes. Typically, ROS/RNS correlate with oxidative damage and cell death; however, free radicals are also crucial for normal cellular functions, including supporting ...
Natalia Jimenez-Moreno, Jon D. Lane, Claudio De Lucia   +2 more
wiley   +1 more source

Modeling the Short-Term Dynamics of in Vivo Excitatory Spike Transmission

Journal of Neuroscience, 2020
Information transmission in neural networks is influenced by both short-term synaptic plasticity (STP) as well as nonsynaptic factors, such as after-hyperpolarization currents and changes in excitability.
Abed Ghanbari, Naixin Ren, Christian Keine, Carl R. Stoelzel, B. Englitz, H. Swadlow, Ian H. Stevenson   +6 more
semanticscholar   +1 more source

Intrinsic Adaptation in Autonomous Recurrent Neural Networks [PDF]

Neural Computation, 2011
A massively recurrent neural network responds on one side to input stimuli and is autonomously active, on the other side, in the absence of sensory inputs. Stimuli and information processing depend crucially on the qualia of the autonomous-state dynamics
Dimitrije Marković, C. Gros
semanticscholar   +1 more source

A Mechanism for Ca2+/Calmodulin-Dependent Protein Kinase II Clustering at Synaptic and Nonsynaptic Sites Based on Self-Association

Journal of Neuroscience, 2005
The activity of Ca2+/calmodulin-dependent protein kinase II (CaMKII) plays an integral role in regulating synaptic development and plasticity. We designed a live-cell-imaging approach to monitor an activity-dependent clustering of green fluorescent ...
A. Hudmon, Eric Lebel, H. Roy, A. Sik, H. Schulman, M. Waxham, P. De Koninck   +6 more
semanticscholar   +1 more source

Synaptic ultrastructural alterations in human focal cortical dysplasia: Insights from volume electron microscopy

Epilepsia, EarlyView.
Abstract Objective Focal cortical dysplasia (FCD) is a developmental malformation of the cerebral cortex and a leading cause of drug‐resistant epilepsy in children and young adults. Disruption of the excitation–inhibition (E–I) balance is a hallmark of neuronal hyperexcitability in FCD, yet the underlying synaptic ultrastructural changes remain poorly ...
Gyu Hyun Kim, Na‐Young Seo, Seung‐Ki Kim, Jae‐Kyung Won, Yang Hoon Huh, Ji Yeoun Lee, Kea Joo Lee   +6 more
wiley   +1 more source