Results 101 to 110 of about 290 (122)

Studies of long-term noopept and afobazol treatment in rats with learned helplessness neurosis

Bulletin of Experimental Biology and Medicine, 2006
Long-lasting effects of new Russian psychotropic drugs Noopept and Afobazol on active avoidance conditioning and formation of learned helplessness neurosis were studied on an original experimental model in rats. Noopept eliminated the manifestations of learned helplessness after long-term (21-day) treatment by increasing the percent of trained animals.
A A, Uyanaev, V P, Fisenko
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Noopept pharmacokinetics after intravenous administration of a lyophilized medicinal form in rats

Pharmaceutical Chemistry Journal, 2007
The pharmacokinetics of noopept, a dipeptide drug possessing nootropic and neuroprotective properties, were evaluated in rats after the intravenous administration of its novel formulation for injections prepared using lyophilization in the presence of mannitol.
S. S. Boiko, V. P. Zherdev, V. P. Kolyvanov, R. U. Ostrovskaya, T. A. Gudasheva, K. S. Us, S. B. Seredenin   +6 more
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Dipeptide preparation Noopept prevents scopolamine-induced deficit of spatial memory in BALB/c mice

Bulletin of Experimental Biology and Medicine, 2007
The effect of original nootropic preparation Noopept on learning and long-term memory was studied with BALB/c mice. Scopolamine (1 mg/kg) impaired long-term memory trace, while Noopept (0.5 mg/kg) had no significant effect. Noopept completely prevented the development of cognitive disorders induced by scopolamine (blockade of muscarinic cholinergic ...
A P, Belnik, R U, Ostrovskaya, I I, Poletaeva   +2 more
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Modulation of the Acetylcholine-Induced Input Current by Noopept in Helix Lucorum Neurons

Biophysics, 2019
Abstract—Possible causes of the positive modulating effect of noopept (in a concentration range of 0.1 to 10 nM) on the amplitude of the acetylcholine-induced input current are analyzed using a developed mathematical model. The results revealed that the calculated and experimental current curves coincide when the number of nicotinic acetylcholine ...
G. B. Murzina, A. S. Pivovarov
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Effect of Noopept and Afobazole on the Development of Neurosis of Learned Helplessness in Rats

Bulletin of Experimental Biology and Medicine, 2003
We studied the effects of new psychotropic preparations noopept and afobazole on acquisition of the conditioned active avoidance response and development of neurosis of learned helplessness in rats. Noopept in doses of 0.05-0.10 mg/kg accelerated acquisition of conditioned active avoidance response and reduced the incidence of learned helplessness in ...
A A, Uyanaev, V P, Fisenko, N K, Khitrov
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Effect of Noopept on Dynamics of Intracellular Calcium in Neurons of Cultured Rat Hippocampal Slices

Bulletin of Experimental Biology and Medicine, 2018
A neuroprotective and nootropic drug Noopept increased the frequency of spontaneous calcium transients in neurons of CA1 radial layer in cultured rat hippocampal slices. In contrast, the drug exerted no significant effect on intracellular calcium concentration and its dynamics in neurons of hippocampal CA1 pyramidal layer.
S N, Kolbaev, O P, Aleksandrova, I N, Sharonova, V G, Skrebitsky   +3 more
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[Anti-inflammatory properties of noopept (dipeptide nootropic agent GVS-111)].

Eksperimental'naia i klinicheskaia farmakologiia, 2002
It is established that single intravenous (0.5 and 5 mg/kg, p.o.) or single peroral (10, 50, 100 mg/kg) and prolonged peroral (5 mg/kg, over 10 days) administration of noopept produces a dose-dependent inhibition of the model inflammatory response to concanavaline A in CBA mice.
L P, Kovalenko, M G, Miramedova, S V, Alekseeva, T A, Gudasheva, R U, Ostrovskaia, S B, Seredenin   +5 more
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Original nootropic drug Noopept prevents memory deficit in rats with muscarinic and nicotinic receptor blockade

Bulletin of Experimental Biology and Medicine, 2008
Antiamnesic activity of Noopept was studied on the original three-way model of conditioned passive avoidance response, which allows studying spatial component of memory. Cholinoceptor antagonists of both types (scopolamine and mecamylamine) decreased entry latency and reduced the probability for selection of the safe compartment.
K S, Radionova, A P, Belnik, R U, Ostrovskaya   +2 more
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[Genotype-dependent mice behavior in cognitive tasks. Effect of noopept].

Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova, 2008
The interstrain differences in performance of C57BL/6J, BALB/c and DBA/2J male mice in two cognitive tasks were found. Mice C57BL/6J showed good learning ability and preservation of memory traces tested 10 days after performance in a simplified version of Morris water maze.
A P, Bel'nik, R U, Ostrovskaia, I I, Poletaeva   +2 more
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Developing analytical methods for the creation of the state reference sample of noopept

Pharmaceutical Chemistry Journal, 2007
The physicochemical properties of noopept, a new domestic original drug with nootropic action, have been studied with a view to developing analytical methods, establishing quality criteria for the parent drug substance, and creating the state reference sample (SRS). These methods will be included in a draft of the regulation on the SRS of noopept.
A. V. Gusev, L. N. Grushevskaya, O. B. Stepanenko, N. I. Avdyunina, B. M. Pyatin, V. P. Lezina, O. S. Anisimova   +6 more
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